activated protein c resistance/obesità

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Obesity and activated protein C resistance.

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It has been reported that obesity may be associated with activated protein C resistance, which could increase the thrombotic risk in these patients. The aim of our study was to evaluate this parameter in obese patients and controls, as well as the effect of weight loss on this parameter. In 63

Incidence of deep venous thrombosis in patients undergoing obesity surgery.

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The aim of this study was to investigate prospectively the incidence of deep venous thrombosis (DVT) after surgery for morbid obesity. The series comprised 116 consecutive patients undergoing Roux-en-Y gastric bypass. The median age and body mass index were 35 years (range 19-59 years) and 42 kg/m2

Activated protein C resistance and the FV:R506Q mutation in a random population sample--associations with cardiovascular risk factors and coagulation variables.

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Activated protein C (APC) resistance, defined as a low APC ratio, is associated with the factor V mutation R506Q (factor V Leiden). APC ratio may also be influenced by other clinical and coagulation variables, which we studied in 460 men and 495 women aged 25-74 years, from a random population

The relationship between body mass index, activated protein C resistance and risk of venous thrombosis.

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BACKGROUND High body mass index (BMI) is associated with an increased risk of venous thrombosis (VT). Clotting factor VIII levels are increased in obese subjects, possibly because of a chronic inflammatory state, which increases activated protein C (APC) resistance. The APC resistance in FV Leiden

The effects of oral contraceptive usage on thrombin generation and activated protein C resistance in Saudi women, with a possible impact of the body mass index.

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OBJECTIVE The effect of oral contraceptive (OC) usage on coagulation has been studied worldwide. However, no such studies have been conducted in Saudi Arabia on Saudi women using OCs. The aim of this study was to investigate the effects of OC-induced changes of thrombin generation (TG) in the

Atherosclerosis in women with endometriosis.

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OBJECTIVE This study aims to determine whether women with endometriosis have greater subclinical atherosclerosis than the general population. METHODS This case-control study included 66 women with endometriosis and 66 controls matched for age and body mass index. All subjects were >or=35 years old.

Clinical profile, common thrombophilia markers and risk factors in 85 young Indian patients with arterial thrombosis.

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OBJECTIVE Arterial thrombosis may occur consequent to hereditary thrombophilia and increased lipoprotein(a) [Lp(a)] and fibrinogen. Our aim was to study the prevalence of common thrombophilia markers in 85 consecutive cases of arterial thrombosis. METHODS A retrospective study was conducted from 85

Superficial vein thrombosis in patients with varicose veins: role of thrombophilia factors, age and body mass.

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OBJECTIVE To investigate the association of various risk factors including thrombophilia defects, in patients with varicose veins (VVs) and history of episodes of superficial vein thrombosis (SVT). METHODS Two hundred and thirty patients with primary VVs were included in this prospective study. A

[Factor V Leiden and the Slovak population].

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The resistance to activated protein C (APC-resistance) based on the presence of factor V Leiden (F V Leiden) is the most frequent thrombophilic condition in the white race population. It contributes to the origin of thrombosis especially in the venous part of blood vessels. Significant geographic

Contraception-related venous thromboembolism in a pediatric institution.

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OBJECTIVE To define the thrombotic risk factors of young women presenting to a children's hospital with hormonal contraception-related venous thromboembolism (VTE). We hypothesized that the majority of patients would have additional risk factors for VTE. METHODS Clinical and laboratory data obtained

[Skin necrosis with vitamin K antagonists: An imbalance between coagulant and anticoagulant factors].

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BACKGROUND Skin necrosis with vitamin k antagonists are rare. They affect more frequently middle-aged and obese women, often within 10 days after initiating of treatment. They occur most often in a context of thrombophilia. METHODS An 18-year-old obese woman was treated with heparin and fluindione

[Brain stem ischemia in a boy with resistance to C activated protein and elevated lipoprotein A].

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BACKGROUND Activated protein C resistance is the most common hereditary coagulation abnormality. In the majority of cases it results from a point mutation Arg506-->Gln of the factor V gene, and characterized by a poor anticoagulant response to activated protein C. METHODS We report the clinical case

High prevalence of thrombophilia among young patients with myocardial infarction and few conventional risk factors.

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BACKGROUND Thrombophilia refers to series of acquired and inherited conditions that confer a tendency to thrombus formation. The exact relationship between thrombophilia and MI is not well established. OBJECTIVE To determine the prevalence of thrombophilia in young patients with their first MI and

Phlegmasia cerulea dolens in a teenage boy found to have Factor V Leiden.

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A 16-year-old boy with morbid obesity and asthma presented with 1 week of progressive right leg pain, swelling and discolouration that started 1 week after a minor fall. Ultrasound and then CT with contrast revealed a large occlusive deep venous thrombosis (DVT) extending from the calf through the

Association between adverse pregnancy outcomes and maternal factor V G1691A (Leiden) and prothrombin G20210A genotypes in women with a history of recurrent idiopathic miscarriages.

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Thrombophilia was implicated in the development of pregnancy complications, including recurrent idiopathic pregnancy loss, and is aggravated in women who are carriers of factor V G1691A (FV Leiden) and prothrombin (PRT) G20210A single-nucleotide polymorphisms (SNPs). Previous studies examined the

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