adrenocortical hyperfunction/obesità

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Effect of Adjustable Intragastric Balloon in Obese Non-alcoholic Fatty Liver Disease

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Introduction: Nonalcoholic fatty liver disease (NAFLD) is an emerging major health problem worldwide which affects a significant proportion of the western population and there is gradual spread of this epidemic to south-east Asian countries. NAFLD encompasses two entities: Non-alcoholic fatty liver

Long-Term Follow-Up of Survivors of Pediatric Cushing Disease

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Objective: Cushing Disease (CD) describes the state of hypercortisolemia secondary to cortisol producing pituitary adenomas. The rarity of the disease (2-5 new cases per million, 1 out of 10 in children) and the subtle initial findings result in prolonged undiagnosed hypercortisolemia, that

Depression & Insulin Sensitivity in Adolescents

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There has been rapid escalation of type 2 diabetes (T2D) rates in adolescents. Early-onset T2D (<20y) typically shows a more aggressive course than adult-onset T2D and disproportionately affects girls from disadvantaged, racial/ethnic groups. This group of girls also is at heightened risk for

Saliva Cortisol Measurement as a Screening Test for Suspicious Cushings Syndrome in Children.

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the investigators have collected saliva samples morning and late evening for cortisol measurements in a total of 330 children ( 660 samples) in the age from 4 to 16 years ols. This samples are going to be used to define a reference range for saliva cortisol in children. The investigators are then

Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas

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Adrenal incidentalomas are unsuspected adrenal masses found during abdominal imaging. With the widespread use of computed tomography and MRI, adrenal incidentalomas are found in approximately 2% of patients. In an endocrinology setting, the majority of these masses are benign adenomas of the adrenal

Effects of IL-1 Beta on the HPA-axis in Obese Persons

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Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism

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Background: - Adrenal incidentalomas are common and found in approximately 4-7% of the population. - About 0.6 to 25% of patients with an adrenal incidentaloma are found to have subclinical hypercortisolism: 2.3% develop subclinical hypercortisolism during follow up and 0.6% develop clinical

Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome

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Adrenal incidentalomas, adrenal tumours detected without symptoms and signs of hormonal hypersecretion or malignancy, are common. Depending on modality (MRI, CT. Ultrasonography) adrenal tumours occur in approximately 1-5% of the population. In about 10% of patients, the tumours are bilateral. At

Influence of nCPAP on Metabolic Consequences Associated With OSAS

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Background: There is evidence that obstructive sleep apnea syndrome (OSAS) increases the risk of cardiovascular events. Sympathetic nervous system and hypothalamic-pituitary-adrenal (HPA) axis activation may be the mechanism of this relationship. We evaluate HPA axis and metabolic consequences in

Diagnostic Performance of Screening Tests for Cushing s Syndrome

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Cushing's syndrome is a rare disorder characterized by a variety of clinical signs and symptoms that reflect chronic exposure to hypercortisolism such as obesity, hypertension, glucose intolerance, infections, psychiatric disturbance, impaired cognition and hypercoagulability. Thus, it is important

Epidemiology of Stress and the Metabolic Syndrome

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BACKGROUND: The metabolic syndrome identifies the clustering of lipid abnormalities, hypertension, hyperglycemia and abdominal obesity. It is a common and strong contributor to heart disease and diabetes and disproportionably affects older persons. Animal and small clinical studies have suggested

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