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alanine/infiammazione
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Pagina 1 a partire dal 23 risultati
.beta.-alanine derivatives
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The invention relates to .beta.-alanine derivatives of the formula I ##STR2##
in which Q.sub.1, Q.sub.2, Q.sub.3 or Q.sub.4 is, in each case, independently of one another, CH or N, R.sup.1 is H, A, Ar, Hal, OH, OA, CF.sub.3 or OCF.sub.3, R.sup.2 is H or A, ##STR3## R.sup.4 and R.sup.5 are, in each
Substituted .beta.-alanine derivatives as cell adhesion inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to novel substituted .beta.-alanine derivatives which are useful for the inhibition and prevention of leukocyte adhesion and leukocyte adhesion-mediated pathologies. This invention also relates to compositions containing such compounds and
3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4
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BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to certain 3-(heteroaryl)alanine derivatives which inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4.
References
The following publications, patents and patent applications are cited in this
3-(heteroaryl) alanine derivatives-inhibitors of leukocyte adhesion mediated by VLA-4
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BACKGROUND OF THE INVENTION
Field of the Invention
This invention relates to certain 3-(heteroaryl)alanine derivatives which inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4.
REFERENCES
The following publications, patents and patent applications are cited in this
Anti-inflammatory peptides and use thereof
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FIELD OF THE INVENTION
The present invention relates to peptides comprising lysine, alanine, leucine and valine, pharmaceutical compositions comprising same, and uses thereof for treating inflammatory conditions and allergy.
BACKGROUND OF THE INVENTION
Antimicrobial Peptides
Lipopolysaccharides
Methods and compositions for modulating C5-a-mediated inflammatory responses
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BACKGROUND OF THE INVENTION
Complement anaphylatoxin C5a is a 74-amino acid peptide generated from the fifth component of complement (C5) during complement activation (Ember et al., Immunopharmacology 38:3, 1997; Gerard, Annu Rev Immunol. 12:775, 1994). C5a acts efficiently as an anaphylatoxin
Treating allergic reactions and inflammatory responses with tri-and dipeptides
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FIELD OF THE INVENTION
The present invention relates to peptides having anti-inflammatory properties. In particular, the present invention relates to peptides through actions on cells that modify the leukocyte recruitment and activation cascade and the actions of mediators released from inflammatory
.beta.-alanine derivates
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This invention relates to a series of alkanoic acid derivatives, to processes for their preparation, and to their use in medicine.
Over the last few years it has become increasingly clear that the physical interaction of inflammatory leukocytes with each other and other cells of the body plays an
Bicyclic heteroaromatic alanines
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This invention relates to a series of bicyclic heteroaromatic alanine derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.
Over the last few years it has become increasingly clear that the physical interaction of inflammatory leukocytes with
Methods of reducing serum alanine transferase levels in a subject with hepatitis
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CROSS-REFERENCE TO RELATED APPLICATION
This application is the U.S. national stage application of International Patent Application No. PCT/EP2003/051090, filed Dec. 22, 2003, the disclosure of which is hereby incorporated by reference in its entirety, including all figures, tables and amino acid or
Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-YL]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof
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FIELD OF THE INVENTION
The invention relates to an amino acid ester compound and to compositions comprising the amino acid ester compound. The invention also relates to use of the compound or composition in the inhibition of the p38 MAP kinase enzyme. In addition, the invention relates to an acid
Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a national phase application under 35 U.S.C. .sctn.371 that claims priority to International Application No. PCT/GB2013/052689 filed Oct. 15, 2013, which claims the benefit of priority to Great Britain Patent Application Nos. 1306881.2
Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]- -3,5-difluorophenyl}ethyl]-L-alaninate or a salt,hydrate or solvate thereof
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FIELD OF THE INVENTION
The invention relates to an amino acid ester compound and to compositions comprising the amino acid ester compound. The invention also relates to use of the compound or composition in the inhibition of the p38 MAP kinase enzyme. In addition, the invention relates to an acid
Interleukin-1 receptor antagonists, compositions, and methods of treatment
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This Application claims the benefit of U.S. Provisional Application No. 60/714,512 filed May 5, 2004.
FIELD OF THE INVENTION
The present invention relates to IL-1 receptor antagonists and methods of modulating IL-1 receptors activity with same. More specifically, the present invention is concerned
Cyclosporins
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BACKGROUND OF THE INVENTION
The present invention relates to cyclosporin derivatives, their production and their use for therapy.
The cyclosporins comprise a group of cyclic, poly-N-methylated undecapeptides having valuable therapeutic properties, particularly as immunosuppressive and
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