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Pagina 1 a partire dal 317 risultati
Endogenous serum albumin content in brain after short-lasting epileptic seizures.
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Epileptic seizures can transiently alter the blood-brain barrier. We have determined the content of extravasated endogenous serum albumin in the brain and its change with time after bicuculline (0.3 mg/kg) induced epileptic seizures of a few minutes' duration in conscious rats. The brains were
Ischemia-modified albumin levels in children having seizure.
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Convulsions are one of the frequently seen problems for a neurologist in the daily routine. It is difficult to distinguish the seizure from pseudo-seizure because of lack of conclusive tests. The aim of this study is to investigate the relationship between seizure types and seizure periods by
Elevation of corazol-induced seizure threshold after active immunization of mice of various genetic strains with glutamate-bovine serum albumin conjugate.
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We studied the effect of active immunization with glutamate-bovine serum albumin conjugate on acute generalized epileptiform activity evoked by single administration of corazol. Antibodies to glutamate produced an antiepileptic effect and elevated the threshold for clonic seizures and tonic phase of
Can ischemia-modified albumin be used to differentiate between generalized seizures and pseudoseizures?
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In recent years ischemia-modified albumin (IMA) has been suggested as a marker that can be used in differentiating nonconvulsive conditions from epilepsy. The purpose of this study was to investigate changes in IMA levels caused by generalized clonic tonic (GTC) seizures.
A total of 114 children
Serum ischemia-modified albumin levels in children with epileptic seizures.
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OBJECTIVE
The aim of the present study was to determine the level of ischemia-modified albumin (IMA) in children with epileptic seizures (ESs) and its relation with the seizure duration.
METHODS
The study was performed with 88 children as a prospective case-control study. Blood samples for IMA were
Novel biochemical marker for differential diagnosis of seizure: ischemia-modified albumin.
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BACKGROUND
Differential diagnosis of seizure is critical in patients presented to emergency department (ED) with altered mental status or loss of consciousness. Although electroencephalogram is important for the diagnosis of seizures, its use in EDs is limited. The level of ischemia-modified albumin
Immunohistochemical localization of extravasated serum albumin in the hippocampus of human subjects with partial and generalized epilepsies and epileptiform convulsions.
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Human serum albumin-like immunoreactivity was detected by the peroxidase-antiperoxidase method in histological sections of the hippocampus from epileptic and control brains obtained on routine autopsies. In the hippocampi of epileptic patients immunoreactive astrocytes were found, the number of
Effect of serum albumin on free fractions of phenobarbital and valproic acid in patients with convulsive seizures.
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The free fractions of phenobarbital and valproic acid were assayed with Free-Level system I (Syva) and by an enzymatic immunoassay technique (EMIT) in 186 patients under chronic anti-convulsant therapy at precisely 2 hrs after they had taken the medicine at breakfast. The free fractions of PB ranged
The effect of acute hypertension on blood-brain barrier permeability to albumin during experimentally induced epileptic seizures.
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The present study was to examine the effect on the blood-brain barrier function of a rapid blood pressure elevation and the duration of this pressure during bicuculline and pentylenetetrazol-induced seizures. The experiments were carried out on Wistar rats. Evans blue was used as a blood-brain
[Familial disease with associated convulsions with very early onset, excess albumin in the cerebrospinal fluid & hyperaminoaciduria].
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Ischemia-modified albumin in patients with seizure.
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Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model.
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Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n-3 PUFA) which has been shown to raise seizure thresholds following acute administration in rats. The aims of the present experiment were the following: 1) to test whether subchronic DHA administration raises seizure threshold in
Seizure-related opening of the blood-brain barrier induced by soman: possible correlation with the acute neuropathology observed in poisoned rats.
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In rats poisoned with soman, an irreversible organophosphate anticholinesterase, acute changes in blood-brain barrier (BBB) permeability to proteins were investigated, using Evans Blue (EB)-labelled serum albumin and plasmatic gamma-immunoglobulin G (IgG) as indicators. Confirming previously
Seizures and hippocampal damage produced by dendrotoxin-K in rats is prevented by the 21-aminosteroid U-74389G.
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The epileptogenic and neurodegenerative effects of dendrotoxin K (DTx-K), from Dendroaspis polylepsis, a specific blocker of a noninactivating, voltage-sensitive K+ channel, were studied after focal injection into one dorsal hippocampus in rats pretreated with the 21-aminosteriod U-74389G, a
Neuronal uptake of serum albumin is associated with neuron damage during the development of epilepsy.
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It is well established that brain blood barrier dysfunction following the onset of seizures may lead to serum albumin extravasation into the brain. However, the effect of albumin extravasation on the development of epilepsy is yet to be fully elucidated. Previous studies have predominantly focused
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