Participants will consume a tablet of 550 mg daily with 250 mg of aged black garlic extract and 300 mg of excipients (microcrystaline cellulose 90 mg; dicalcium phosphate 157 mg; crosscamellose sodium 10 mg; magnesium stearate 7 mg; sodium alignate 3.06 mg; stearic acid 0.03 mg; oleic acid 1.54 mg; medium chain triglycerides 2.80 mg; ethylcellulose 13.17 mg; hydroxypropylcellulose 4.86 mg; hydroxypropylmethylcellulose 4.86 mg; talcum 2.88 mg; titanium dioxide 1.80 mg; vanilla aroma 1.00 mg) .

Participants will consume a tablet of 550 mg daily with 550 mg of excipients (microcrystaline cellulose 342.5 mg; dicalcium phosphate 154.5 mg; crosscamellose sodium 10 mg; magnesium stearate 7 mg; sodium alignate 3.06 mg; stearic acid 0.03 mg; oleic acid 1.54 mg; medium chain triglycerides 2.80 mg; ethylcellulose 13.17 mg; hydroxypropylcellulose 4.86 mg; hydroxypropylmethylcellulose 4.86 mg; talcum 2.88 mg; titanium dioxide 1.80 mg; vanilla aroma 1.00 mg).

Cardiovascular Diseases

Participants will intake a tablet with 250 mg of a aged black garlic extract with higher concentration of bioactive compounds S-allyl cysteine and alliin, and minor unwanted compounds such as simple sugars and furfural derivatives.
In addition, during the course of the study, participants will be urged to follow dietary guidelines according to a heart-healthy diet established by nutritionists and that they will adhere to European guidelines for the treatment of dyslipidemias.

Aged black garlic extract

Participants will intake a tablet with 250 mg of microcrystalline cellulose. In addition, during the course of the study, participants will be urged to follow dietary guidelines according to a heart-healthy diet established by nutritionists and that they will adhere to European guidelines for the treatment of dyslipidemias.

Placebo

Technological Centre of Nutrition and Health. Eurecat_Reus.

Centro Tecnológico de Nutrición y Salud (Eurecat-Reus)

Effect of a Black Garlic Extract on Cholesterol LDL Levels

Effect of a Black Garlic Extract With Greater Concentration of Bioactive Compounds and Lower Content in Undesired Compounds on Cholesterol LDL Levels. Chronic, Randomized, Crossover, Controled and Double Blind Study

Serum LDL-c levels will be measured by standardized methods in Cobas Mira Plus autoanalyzer (Roche Diagnostics Systems, Madrid, Spain).

Weight and height will be combined to report BMI in kg/m^2.

Waist circumference using a measuring tape.

Systolic and diastolic blood pressure will be measured twice after 2-5 minutes of patient respite, seated, with one-minute interval in between, using an automatic sphygmomanometer (OMRON HEM-907; Peroxfarma, Barcelona, Spain).

Total cholesterol, HDL-c, TG, NEFAs, Apo B and Apo A1 plasma levels will be measured by standardized methods in Cobas Mira Plus autoanalyzer (Roche Diagnostics Systems, Madrid, Spain). oxLDL, PLTP plasma levels will be measured by human ELISA kits.

Glucose and insulin plasma levels will be measured by standardized methods in Cobas Mira Plus autoanalyzer (Roche Diagnostics Systems, Madrid, Spain).

IL-6 plasma levels will be measured by standardized methods in Cobas Mira Plus autoanalyzer (Roche Diagnostics Systems, Madrid, Spain). MCP-1 and TNF alpha will be measured by human ELISA kits.

Technological Centre of Nutrition and Health, Spain

Eurecat

Hospital Universitari Sant Joan de Reus

University Rovira i Virgili

Pharmactive Biotech Products S.L.

The consumption of SANE and placebo will be in the form of tablets with the same appearance, of 550 mg / tablet, guaranteeing that the study is blind both for the researchers of the project and for the participants (double blind).

this group will receive ginger drink made by dissolving 4g ginger powder in plain water once a day for continuous 5 days.

this group will receive ginger drink made by dissolving 4g ginger powder in plain water twice a day for continuous 5 days.

Platelets Dysfunction

Hematological Diseases

Ginger drink

King Abdulaziz Medical City - National Guard Hospital

Daily Ginger Drinking and Platelet Function

The Effect of Daily Ginger Drinking on Platelet's Function in the Saudi Population

King Abdullah International Medical Research Center

Budesonide inhaler as experimental treatment along with placebo pill.

Acetazolimide pill as active comparator along with sham inhaler.

Sham inhaler as control for budesonide inhaler along with placebo pill as control for acetazolamide comparator.

Budesonide inhaler as experimental treatment along with placebo pill.
Budesonide: Inhaled Budesonide vs. PO Acetazolamide vs. Placebo for prevention of Acute Mountain Sickness

Budesonide

Acetazolimide pill as active comparator along with sham inhaler.
Acetazolamide: Inhaled Budesonide vs. PO Acetazolamide vs. Placebo for prevention of Acute Mountain Sickness

Acetazolamide

Sham inhaler as control for budesonide inhaler along with placebo pill as control for acetazolamide comparator.
Placebo: Placebo pill and sham inhaler

Control

Total

Sex: Female, Male

Region of Enrollment

Number of participants with acute mountain sickness (AMS) by Lake Lousie Questionnaire (LLQ)

Number of Participants With Acute Mountain Sickness

Number of participants with severe acute mountain sickness (AMS) by Lake Lousie Questionnaire (LLQ) (score > 5).

Number of Participants With Severe Acute Mountain Sickness

measurement of oxygen saturation (%) by finger tip pulse oximeter.

Oxygen Saturation

Overall Study

Dr. Grant Lipman

Acute Mountain Sickness

Inhaled Budesonide vs. PO Acetazolamide vs. Placebo for prevention of Acute Mountain Sickness

Owens Valley Lodge - White Mountain Research Station

Altitude Sickness Prevention and Efficacy of Comparative Treatments

A Randomized Controlled Trial of Altitude Sickness Prevention and Efficacy of Comparative Treatments

Grant S Lipman

Associate Professor Department of Emergency Medicine

Stanford University

Procalcitonin, CRP, IL-6, IL-10, Leukocytes, Thrombocytes, Bilirubin, Creatinine, Lactate, Albumin, AT-III

allium/nausea

Effect of a Black Garlic Extract on Cholesterol LDL Levels

Daily Ginger Drinking and Platelet Function

Altitude Sickness Prevention and Efficacy of Comparative Treatments

Prospective, Non-randomized Observational Trial of Selenium in Cardiac Surgery

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