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ambrosia polystachya/albumina
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The nature of melon allergy in ragweed-allergic subjects: A study of 1000 patients.
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Previous studies suggest cross-reactivity between specific ragweed pollen and melon allergens. This study was designed to clarify the origin of the cross-reactivity between ragweed pollen and the gourd family. One thousand ragweed-allergic subjects were interviewed about the presence of oral allergy
The localization of skin-sensitizing antibody in the sera of ragweed-sensitive individuals by electrophoresis.
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Starch electrophoresis was used to separate allergic sera into electrophoretically distinct albumin, alpha-, beta-, and gamma-globulin fractions. The identity of the various fractions was established by free and paper electrophoresis. The gamma-globulin fractions were also characterized by
Local intranasal immunotherapy for ragweed allergic rhinitis. II. Immunologic response.
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Local nasal immunotherapy (LNIT) was administered in a double-blind study to 67 subjects. Twenty-three received an unmodified ragweed extract (RW), 24 received a glutaraldehyde polymer of ragweed extract (PRW), and 21 received placebo. Serum ragweed-specific IgE (S-IgE), ragweed-specific nasal
The antibody mechanisms of ragweed allergy; electrophoretic and chemical studies. I. The blocking antibody.
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Three human serums containing artificially produced blocking antibody against low ragweed allergen were studied for the possibility of relating blocking antibody to electrophoretically definable components. An adaptation of the qualitative passive transfer test to quantitative interpretation is
The association of skin-sensitizing antibody with the beta 2A-globulins in sera from ragweed-sensitive patients.
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1. The removal of the beta(2)A-globulins from three sera from treated ragweed-sensitive individuals by immune absorption was associated with the loss of all detectable skin-sensitizing antibody activity as demonstrated by Prausnitz-Küstner testing. 2. Gel filtration studies, with sephadex G-200,
Ragweed hay fever: treatment by local passive administration of IgG antibody.
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To determine whether the local administration of IgG antibodies might reduce the symptoms of ragweed hay fever, we tested the effect of this treatment in fourteen patients in a double-blind pilot trial. The patients were randomly divided into two groups, treatment and placebo, and their symptoms and
Pulmonary inflammation after segmental ragweed challenge in allergic asthmatic and nonasthmatic subjects.
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Inflammatory reactions in the airways are thought to play an important role in asthma pathogenesis. The goal of this work was to test prospectively the hypothesis that the pulmonary inflammatory response to segmental antigen challenge is greater in allergic asthmatic (AA) subjects than in allergic
Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis.
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BACKGROUND
Conjugating immunostimulatory sequences of DNA to specific allergens offers a new approach to allergen immunotherapy that reduces acute allergic responses.
METHODS
We conducted a randomized, double-blind, placebo-controlled phase 2 trial of a vaccine consisting of Amb a 1, a
Pollen grains as a novel microcarrier for oral delivery of proteins.
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Oral delivery of proteins and peptides is a challenge due to their degradation in the stomach. To overcome this challenge, ragweed (Ambrosia elatior) pollen grains were engineered to serve as protective microcapsules. A matrix comprising of Eudragit L100-55, an enteric polymer was deposited on the
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