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arthritis/phosphatase
Il collegamento viene salvato negli appunti
Pagina 1 a partire dal 24 risultati
TNF and IL23 Blocking Agents Gene Expression Ratios in the Psoriatic Arthritis Synovium_(TIGERS) Study
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1. STUDY SYNOPSIS 1.1 Rationale Psoriatic arthritis (PsA) is a chronic inflammatory disease, leading to impaired function, reduced quality of life, comorbidities and increased mortality. Fortunately, improved knowledge about disease mechanisms catalyzed rapid development of effective targeted
Cardiovascular Profiles in Rheumatoid Arthritis
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Patient Selection:
Screen ~400 Rheumatoid Arthritis (RA) patients followed in Centro Hospitalar do Porto outpatient clinic. All RA patients with regular follow-up will be potentially included.
The investigators also aim to enrol age-matched controls for biomarker comparison.
Experimental
The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients
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In a prospective, randomized clinical trial of de novo mandibular fracture patients requiring intraoral surgical repair with plating, the investigators will:
1. Compare the effects of supplemental vitamin C to placebo on soft tissue wound healing, measured by a) biomarkers of soft tissue repair
ObeSity Related Colorectal Adenoma Risk
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Bowel cancer, or colorectal cancer (CRC), is the second most common cancer affecting both men and women in England. The majority of CRCs develop from a pre-cancerous type of growth in the bowel called an adenoma. Detecting and removing these adenomas is important in reducing CRC risk. A study which
Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus
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Charcot's neuroarthropathy has been identified since 1883, yet we have much to learn about the pathophysiology and evidence based treatment options. Active CNO is characterised by repetitive trauma leading to inflammation in an insensate foot. This includes polypeptide receptor activator of nuclear
Dose Effect Relationship of MTX and IBD
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Inflammatory bowel disease is a chronic, relapsing and remitting, inflammatory disorder of the GI tract. The mainstay of medical therapy is comprised of 5-aminosalicylates, corticosteroids, immunomodulators such as mercaptopurine and MTX, and biologics such as infliximab and
Probiotics for Modic Changes in Low Back Pain Patients
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Background information on trial preparation The bacteria Lactobacillus rhamnosus GG is an anaerobic gram-positive rod that among other areas exists as a part of the body's normal intestinal flora. In the intestine the bacteria breaks down carbohydrates to form lactic acid. The bacteria is tolerant
The Efficacy and Safety of the Xue-Fu-Zhu-Yu Capsule in Treatment of Qi Stagnation and Blood Stasis Syndrome.
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Alendronate Treatment of Osteoporosis in Rheumatoid Arthritis
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Primary objectives:
- to assess the effect of discontinuation of alendronate (ALN) on C-terminal telopeptide crosslinks (CTX) and Type 1 procollagen amino-terminal-propeptide (P1NP) after 6 months
- to assess the effect of discontinuation of ALN on bone mineral density (BMD) on DXA scans at 2
Efficacy and Safety of Ginseng Extract on Improvement of Bone Metabolism in Menopausal Women
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The investigators performed a 12-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of ginseng extract on improvement of Bone metabolism in menopausal women. The investigators measured Serum Osteocalcin, Urinary Deoxypyridinoline, DPD/OC ratio, Serum
Longjohn Amgen Study - Effect of Denosumab...
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EXPERIMENTAL PLAN Study Design The proposed study is a Phase 3, double-blinded, randomized controlled study. All of the 80 patients, both placebo and denosumab groups, will adhere to the same protocol. Patient screening will be performed by the orthopaedic surgeons (Donald Longjohn, MD and Daniel
Quantification of GADD34 Expression in RA
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The endoplasmic reticulum (ER) is the subcellular compartment where transmembrane and secreted proteins are produced. In normal conditions biosynthesis rate, folding and trafficking of the proteins are tightly regulated through an efficient 'quality control' system. The ER responds to the
Umbilical Cord Mesenchymal Stem Cells for Patients With Primary Biliary Cirrhosis
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Primary biliary cirrhosis (PBC) is a slowly progressive cholestatic disease associated with the development of cirrhosis and liver failure that may justify liver transplantation. Ursodeoxycholic acid (UDCA) is currently the only drug approved specifically for the treatment of PBC. However, one out
Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis
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Objectives:
1. Assess the influence of immune system cells in the modulation of bone turnover in patients with RA, AS and healthy donors (Task 2).
2. Analyze the osteoclast precursors and their differentiation into fully functional osteoclasts in a subgroup of patients with RA, AS and healthy donors
Bovine Intestinal Alkaline Phosphatase (bIAP) Modulating Rheumatoid Arthritis
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This is a proof of concept study to establish the safety of subcutaneous (sc) treatment and the efficacy of alkaline phosphatase (AP) in reducing specific pro-inflammatory cytokines during and after 3 days of twice daily s.c. treatment. A total dose of 12000 Units AP will be administered by 2000 IU
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