Arthritis / tyrosine

Homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof

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FIELD OF THE INVENTION This invention relates to compounds which are inhibitors of protein tyrosine kinases, such as the Janus kinases, and to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases comprising administering to a

Sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use therof

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FIELD OF THE INVENTION This invention relates to compounds which are inhibitors of protein tyrosine kinases, such as the Janus kinases, and to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases comprising administering to a

Tyrosine kinase inhibitors

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The present disclosure provides compounds that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as

Tyrosine kinase inhibitors

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The present disclosure provides compounds that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as

Tyrosine kinase inhibitors

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The present disclosure provides compounds that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as

Tyrosine kinase inhibitors

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Entra registrati

The present disclosure provides compounds that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as

Tyrosine kinase inhibitors

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Entra registrati

The present disclosure provides compounds that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as

Tyrosine kinase inhibitors

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Entra registrati

The present disclosure provides compounds that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as

Azaindole derivatives as tyrosine kinase inhibitors

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The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, JAK3, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such

Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors

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The present disclosure provides compounds and pharmaceutically acceptable salts that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, Jak3, TEC, Btk, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as

Inhibitor of bruton's tyrosine kinase

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This application is a national phase of International Application No. PCT/CN2015/078453 filed May 7, 2015, which claims priority to Application No. CN 201410191608.7 filed May 7, 2014. FIELD OF THE INVENTION This invention pertains to a series of multi-substituted five-membered heterocyclic

Inhibitors of bruton's tyrosine kinase

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FIELD OF THE INVENTION This invention pertains to compounds that inhibit irreversible bruton's tyrosine kinases, compositions containing the compounds and methods of treating diseases using the compounds. BACKGROUND OF THE INVENTION Protein kinases, the largest family of human enzymes, encompass

Tyrosine alkoxyguanidines as integrin inhibitors

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FIELD OF THE INVENTION The present invention relates to novel tyrosine alkoxyguanidine compounds that are inhibitors of alpha V (.alpha.v) integrins, for example .alpha.v.beta.3 and .alpha.v.beta.5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions

Use of tyrosine kinase inhibitors for treating inflammatory diseases

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The present invention relates to a method for treating inflammatory diseases such as rheumatoid arthritis (RA), comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor

Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors

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FIELD OF THE INVENTION This invention relates to compounds which are inhibitors of protein tyrosine kinases, such as the Janus kinases, and to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases comprising administering to a

arthritis/tyrosine

Homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof

Sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use therof

Tyrosine kinase inhibitors

Tyrosine kinase inhibitors

Tyrosine kinase inhibitors

Tyrosine kinase inhibitors

Tyrosine kinase inhibitors

Tyrosine kinase inhibitors

Azaindole derivatives as tyrosine kinase inhibitors

Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors

Inhibitor of bruton's tyrosine kinase

Inhibitors of bruton's tyrosine kinase

Tyrosine alkoxyguanidines as integrin inhibitors

Use of tyrosine kinase inhibitors for treating inflammatory diseases

Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors

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