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13 risultati
Method for reducing neuronal degeneration associated with seizure
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BACKGROUND OF THE INVENTION
Morphological changes occur in the adult vertebrate brain both during normal learning and in various neuropathologies such as epilepsy and Alzheimer's disease (Refs. 1-3). These changes include neurodegeneration and more subtle remodeling of the cellular architecture, and
Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device
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BACKGROUND OF THE INVENTION
The present invention is in the field of medical devices to treat neurological disorders of the brain. More specifically, the invention is directed to a method and a partially or fully implanted apparatus for predicting and detecting epileptic seizure onsets within a
Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists
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BACKGROUND OF THE INVENTION
1. Field of the Invention The present invention relates to novel tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidine compounds that are antagonists of alpha V (.alpha.v) integrins, for example .alpha..sub.v.beta..sub.3 and .alpha..sub.v.beta..sub.5 integrins, their
8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/NMDA receptor
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FIELD OF THE INVENTION
The present invention is in the field of medicinal chemistry. In particular, the present invention relates to substituted and unsubstituted 8-aza, 6-aza, and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones as well as N-oxides thereof and pharmaceutically acceptable salts thereof
Tricyclic dicarbonyl derivatives
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This is a 371 application of PCT/EP95/01856, filed May 16, 1995. The present invention is concerned with tricyclic dicarbonyl derivatives of the general formulae ##STR2## wherein R.sup.1 and R.sup.2 each independently signify hydrogen, lower alkyl, lower alkoxy, nitro, trifluoromethyl, amino,
Therapeutic use of antibodies directed against repulsive guidance molecule (RGM)
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This application is the United States national stage of International Application No. PCT/EP01/15289, filed Dec. 21, 2001, which was published under PCT Article 21(2) in English as International Publication No. WO 02/051438, and which claims benefit of European Patent Application No. 00128356.3
Deuterium-enriched alkyl sulfonamides and uses thereof
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FIELD OF THE INVENTION
The present invention generally relates to deuterium-enriched N-acetylamino-(piperazinyl)-butyl)-alkylsulfonamides of formula 1, their pharmaceutically acceptable salts, synthesis and methods of use thereof. These compounds are 5-HT (serotonin) receptor modulators more
Heterocycles as potassium channel modulators
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BACKGROUND OF THE INVENTION
Ion channels are cellular proteins that regulate the flow of ions, including calcium, potassium, sodium and chloride, into and out of cells. These channels are present in all human cells and affect such processes as nerve transmission, muscle contraction and cellular
Heterocycles as potassium channel modulators
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BACKGROUND OF THE INVENTION
Ion channels are cellular proteins that regulate the flow of ions, including calcium, potassium, sodium and chloride, into and out of cells. These channels are present in all human cells and affect such processes as nerve transmission, muscle contraction and cellular
Heterocycles as potassium channel modulators
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BACKGROUND OF THE INVENTION
Ion channels are cellular proteins that regulate the flow of ions, including calcium, potassium, sodium and chloride, into and out of cells. These channels are present in all human cells and affect such processes as nerve transmission, muscle contraction and cellular
NMDA NR2B antagonists for treatment
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FIELD OF THE INVENTION
This invention relates to the treatment of neurological disorders. This invention also relates to the treatment of depression. More particularly, this invention relates to treatment of hearing loss, vision loss, neurodegeneration caused by epileptic seizures, neurotoxin
NMDA NR2B antagonists for treatment
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FIELD OF THE INVENTION
This invention relates to the treatment of neurological disorders. This invention also relates to the treatment of depression. More particularly, this invention relates to treatment of hearing loss, vision loss, neurodegeneration caused by epileptic seizures, neurotoxin
Use of RGM and its modulators
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SEQUENCE LISTING
A sequence listing in accordance with 37 C.F.R. .sctn..sctn.1.821-1.825 is attached to the present invention and contained in a file named "8085USC2.txt" (28 Kb, created on Jun. 4, 2012) and is herein fully incorporated by reference.
The present invention relates to the use of a
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