50 healthy volunteers. Intervention: Lung sound recording for part A(i) of the study.

100 patients with wheezing and/or crackles due to respiratory disease. Intervention: Lung sound recording for part A(ii) of the study.

25 patients who are scheduled to have a Bronchoscopy as part of their standard care and are identified by a medical professional as having a 'normal' lung structure.
Intervention: Lung sound transmission measurement for part B(i) of the study.

25 patients who are scheduled to have a Bronchoscopy as part of their standard care and are identified by a medical professional as having an 'abnormal' lung structure.
Intervention: Lung sound transmission measurement for part B(ii) of the study.

Bronchomalacia

Asthma

Lung Neoplasms

Lung Diseases, Interstitial

Pulmonary Disease, Chronic Obstructive

Sound at chest wall is recorded using a sensor array during the bronchoscopy procedure, while a sound is played down the working channel of the bronchoscope.

Lung sound transmission measurement

Lung sounds are recorded using a sensor array.

Lung sound recording

Cambridge University Hospitals and the University of Cambridge

Mapping Sound Propagation Through the Human Lung for Better Diagnosis

This will use a hypothesis test on features extracted from the time-series array data in Part B of the study.

This will consist of acoustic data from an array of acoustic sensors on the posterior back, acoustic data from the sound source, photographs of the back with sensor locations and key anatomical features marked and thorax CT scans. This database will be used to investigate propagation mechanisms and localisation techniques.

This will consist of acoustic data from an array of acoustic sensors at the posterior chest of supine participants taken while these perform a series of breathing exercises. The database will also include basic biometric data.

Non-identifiable patient data will be used in publications and made available on the University of Cambridge's data repository DSpace when the results of the study are published.

bronchomalacia/tosse

Mapping Sound Propagation Through the Human Lung for Better Diagnosis

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