Patient will be on amoxicillin-clavulanate 22.5mg/kg/dose bd for 10 days

Patient will be on amoxicillin-clavulanate 22.5mg/kg/bd for 3 days followed by another 7 days of placebo medication given at the same dose and frequency

Pneumonia

Amoxicillin-Potassium Clavulanate Combination

Placebo made to look like the study drug-main ingredient sugar syrup made by the pharmacy department in the hospital In the placebo arm, patient will be given 3 days of antibiotic followed by 7 days of placebo

Placebo

University Malaya Medical Centre

Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life

Complete resolution of symptoms. No treatment failure or exit failure i.e. need for antibiotics or readmission into hospital for a respiratory condition

Severity of cough by using the translated and validated PCQOL-8 to assess impact of cough on the child and parent.

Using the translated and validated DASS21 on parents

Using the translated and validated the Canadian Acute Respiratory Influenza Scale(CARIFS)

Treatment related adverse effects of antibiotics e.g. diarrhoea, vomiting

Time to the next hospitalization or visit to the doctor for respiratory symptoms

proportion of children hospitalised for respiratory illness or need for unscheduled healthcare visits

Bacterial isolates: resistance pattern, resolution or persistence. Viral isolates: positive or negative These will be assessed at admission and 4 weeks post-discharge

Radiological resolution and correlation with respiratory symptoms

Presence of respiratory symptoms and signs e.g. cough, failure to thrive, reduced effort tolerance, clubbing, persistent respiratory signs

To see if the extended antibiotic course is cost effective

Anna Marie Nathan

Consultant and Associate Professor

University of Malaya

Menzies School of Health Research

Inj. Ceftriaxone and other micronutrients will be given to children at the day-care clinic from 8:00 a.m. to 5:00 p.m. daily.

Hospital management: all children admitted at the hospital will be managed with injection Ceftriaxone and other micronutrients for the total duration of hospitalization as per approved protocol.

Malnutrition

Day-care clinic

Inj. Ceftriaxone and other micronutrients will be given to children at the hospital from admission till discharge.

Hospital Management

International Centre for Diarrhoeal Disease Research Bangladesh

Trial in Childhood Pneumonia With Malnutrition

Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children

chlamydia infections/hypoxia

Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

Trial in Childhood Pneumonia With Malnutrition

Diagnosis of Ventilator- Associated Pneumonia in Children: A Comparative Study of Bronchoscopic and Non-Bronchoscopic Methods

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