Patient will be on amoxicillin-clavulanate 22.5mg/kg/dose bd for 10 days

Patient will be on amoxicillin-clavulanate 22.5mg/kg/bd for 3 days followed by another 7 days of placebo medication given at the same dose and frequency

Pneumonia

Amoxicillin-Potassium Clavulanate Combination

Placebo made to look like the study drug-main ingredient sugar syrup made by the pharmacy department in the hospital In the placebo arm, patient will be given 3 days of antibiotic followed by 7 days of placebo

Placebo

University Malaya Medical Centre

Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life

Complete resolution of symptoms. No treatment failure or exit failure i.e. need for antibiotics or readmission into hospital for a respiratory condition

Severity of cough by using the translated and validated PCQOL-8 to assess impact of cough on the child and parent.

Using the translated and validated DASS21 on parents

Using the translated and validated the Canadian Acute Respiratory Influenza Scale(CARIFS)

Treatment related adverse effects of antibiotics e.g. diarrhoea, vomiting

Time to the next hospitalization or visit to the doctor for respiratory symptoms

proportion of children hospitalised for respiratory illness or need for unscheduled healthcare visits

Bacterial isolates: resistance pattern, resolution or persistence. Viral isolates: positive or negative These will be assessed at admission and 4 weeks post-discharge

Radiological resolution and correlation with respiratory symptoms

Presence of respiratory symptoms and signs e.g. cough, failure to thrive, reduced effort tolerance, clubbing, persistent respiratory signs

To see if the extended antibiotic course is cost effective

Anna Marie Nathan

Consultant and Associate Professor

University of Malaya

Menzies School of Health Research

Half of enrolled women will be randomly assigned to group 1.

Half of enrolled women will be randomly assigned to group 2

Endometritis

Two capsules of Doxycycline 100 mg before vacuum aspiration Placebo "100 mg" twice daily for 5 days after vacuum aspiration (appearance of capsules is the same for both groups)

Doxycycline pre-operatively

Two capsules of placebo "100 mg" before vacuum aspiration Doxycycline 100 mg twice daily for 5 days after vacuum aspiration (appearance of capsules is the same for both groups)

Doxycycline post-operatively

Tu Du Hospital

Doxycycline Prophylaxis at Vacuum Aspiration Trial

Efficacy and Side-Effects of Two Dosing Regimens of Doxycycline at Surgical Abortion: A Randomized Double-Blind Trial

Matthew Reeves

University of Pittsburgh

Subjects residing in villages assigned to treatment arm 1 will receive a clinical evaluation for trachoma and provide a swab specimen of conjunctivae of the R eye at enrollment (Day 0); will be treated with Azithromycin at Day 30; will be re-screened (clinical evaluation and swab specimen of R eye collected) at Day 60; and again at Day 360.

Subjects residing in villages assigned to treatment arm 2 will receive a clinical evaluation for trachoma and provide a swab specimen of conjunctivae of the R eye at enrollment (Day 0), as well as receive an initial treatment with Azithromycin; will receive a second dose of Azithromycin at Day 30; will be re-screened (clinical evaluation and swab specimen of R eye collected) at Day 60; and again at Day 360.

Trachoma

1 gm Azithromycin orally, provided as four 250 mg tablets for adults; pediatric suspension will be provided to children > 1 year old (20 mg/kg body weight) to a maximal dose of 500 mg. One dose vs 2 doses given 30 days apart.

chlamydia infections/vomito

Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

Doxycycline Prophylaxis at Vacuum Aspiration Trial

Azithromycin in Control of Trachoma II

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