diphtheria/potassio

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Effect of potassium depletion of cells on their sensitivity to diphtheria toxin and pseudomonas toxin.

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When Vero cells were depleted of potassium, the cells were protected against diphtheria toxin. Potassium depletion of Vero cells strongly reduced the binding of the toxin to cell surface receptors. Likewise, potassium depleted L-cells were protected against pseudomonas toxin. Diphtheria toxin

Needle-Free Dermal Delivery of a Diphtheria Toxin CRM197 Mutant on Potassium-Doped Hydroxyapatite Microparticles.

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Injections with a hypodermic needle and syringe (HNS) are the current standard of care globally, but the use of needles is not without limitation. While a plethora of needle-free injection devices exist, vaccine reformulation is costly and presents a barrier to their widespread clinical application.

[Contents of sodium, potassium and calcium ions in the blood serum of horses during various steps of immunization with diphtheria antigen and in horses treated with tetanus antigen].

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Potassium Tellurite in Diphtheria Diagnosis.

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Alternation to toxoid of diphtheria toxin by potassium thiocyanate.

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Diphtheria toxoid obtained by the treatment with potassium thiocyanate.

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[Effect of potassium and sodium ions on the synthesis of diphtheria toxin].

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[ON CHANGES IN THE SODIUM AND POTASSIUM IN INDIVIDUAL HEART AREAS AFTER DAMAGE WITH QUININE AND DIPHTHERIA TOXIN AND AFTER TREATMENT WITH G-STROPHANTHIN IN VIVO].

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An early effect of diphtheria toxin on the metabolism of mammalian cells growing in culture.

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At concentrations of 0.1 Lf (0.25 microg.)/ml., or greater, diphtheria toxin produces an immediate decrease (40 +/- 5 per cent) in the steady-state level of incorporation of inorganic phosphate into ATP by cultures of normal human kidney cells growing at 37 degrees C. in the presence of glucose. The

Requirement of a transmembrane pH gradient for the entry of diphtheria toxin into cells at low pH.

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The effects of acidification of the cytosol and of electrical depolarization on the entry of diphtheria toxin were studied. Entry of the toxin from the cell surface was induced by low pH, and the presence of the toxin in the cytosol was monitored as toxin-induced inhibition of protein synthesis. To

On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.

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Diphtheria toxin (DT) in acidic media forms ion-conducting channels across the plasma membrane and inhibits protein synthesis of both highly and poorly DT-sensitive cell lines. This results in loss of cell potassium and in entry of both sodium and protons with a concomitant rapid lowering of

In vitro inhibition of diphtheria toxin action by ammonium salts and amines.

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Kim, K. (University of Washington, Seattle), and N. B. Groman. In vitro inhibition of diphtheria toxin action by ammonium salts and amines. J. Bacteriol. 90:1552-1556. 1965.-An inhibitor for diphtheria toxin action on HeLa cells was demonstrated in the growth supernatant fractions of both

Interactions of diphtheria toxin with lipid vesicles: determinants of ion channel formation.

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Lipid vesicles have been utilized to study the interactions of diphtheria toxin (DT) with membranes. The assay for DT ion channel formation was fluorescence-detected membrane potential depolarization of vesicles in which valinomycin-induced potassium diffusion gradients had been generated. The

Crystalline pneumococcus antibody.

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1. The immune precipitate formed by antipneumococcus horse serum and the specific polysaccharide is not hydrolyzed by trypsin as is the diphtheria toxin-antitoxin complex, and purified pneumococcus antibody cannot be isolated by the method used for the isolation and crystallization of diphtheria

A STUDY OF THE ELIMINATION OF PHENOLSULPHONEPHTHALEIN IN VARIOUS EXPERIMENTAL LESIONS OF THE KIDNEY.

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The study of a variety of experimental renal lesions in the dog demonstrates that the phenolsulphonephthalein test of Rowntree and Geraghty is one of the most satisfactory and at the same time most delicate methods of estimating the functional activity of the kidney. The elimination of the test dye

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