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15 risultati
Genes involved in stroke response and/or regulated by FK506, proteins encoded thereby, and methods of use
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FIELD OF THE INVENTION
The present invention relates to genes and the proteins encoded thereby which are involved in neurotoxicity and/or are regulated by FK506. Polynucleotides were discovered using in vivo or in vitro models by determining which genes were differentially upregulated or
Dual beneficial effect of dopamine enhancing and neuroprotective actions of PKC delta inhibitors for treatment of Parkinson's disease
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FIELD OF THE INVENTION
This invention relates to methods and pharmaceutical compositions for regulating the levels of dopamine using a protein kinase C delta (PKCd) inhibitor. In particular, it relates to increasing the levels of dopamine in the central nervous systems (CNS) and in the treatment of
Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like
Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like
Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
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BACKGROUND OF THE INVENTION
Dopamine is a neurotransmitter found in various parts of the central nervous system. It is most prevalent in the substantia nigra (A9), the neostriatum, and the ventral tegmental area (A10). Dopamine binds to two general classes of receptors, termed D1- and D2-like
Sensors for detecting substances indicative of stroke, ischemia, or myocardial infarction
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BACKGROUND OF THE INVENTION
Description of the Related Art
The present invention generally relates to the use of sensors to monitor the concentration of a chemical species in bodily fluids. More specifically, the present invention relates to the use of sensors to monitor glucose levels, and/or other
Human applications of controlled stress
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a human analog to the tail pinch effect utilized in animals and, more particularly, to methods, apparatus, systems and techniques for modifying human behavior, for treating certain diseases and affecting other human
2-carbonylthiazole derivatives and use of the same
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TECHNICAL FIELD
This invention relates to a 2-carbonylthiazole derivative having antipsychotic action.
BACKGROUND ART
Antipsychotic drugs are used for the treatment of not only schizophrenia but also problematic behavior (such as aggressive behavior, mental excitation, poriomania and delirium)
Polymeric device for controlled drug delivery to the CNS
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BACKGROUND OF THE INVENTION
Many drugs exist which pass the blood brain barrier and are therefore suitable for the treatment of certain disorders of the central nervous system. However, a number of additional substances exist which are of potential clinical usefulness, but that do not pass through
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
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FIELD OF THE INVENTION
The present invention relates to certain diaryl and arylheteroaryl urea derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
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FIELD OF THE INVENTION
The present invention relates to certain diaryl and arylheteroaryl urea derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT.sub.2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
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Entra registrati
FIELD OF THE INVENTION
The present invention relates to certain diaryl and arylheteroaryl urea derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT.sub.2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
Solo gli utenti registrati possono tradurre articoli
Entra registrati
FIELD OF THE INVENTION
The present invention relates to certain diaryl and arylheteroaryl urea derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
Method of treating Parkinson's disease
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FIELD OF THE INVENTION
The invention relates to the fields of molecular biology and medicine. More particularly, the invention relates to methods for treating neurodegenerative diseases including Parkinson's disease and stroke in mammalian subjects.
BACKGROUND
Neuronal death plays a critical role in
1,4-disubstituted piperazine ligands for neurotransmitter receptors
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BACKGROUND OF THE INVENTION
Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed in animals and plants, occurring in vertebrates, fruits, nuts, and venoms. A number of congeners of serotonin are also found in nature and have been shown to possess a variety of peripheral and central nervous
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