Pagina 1 a partire dal 58 risultati
This invention relates to a method of determining human acid glutathione S-transferase in a human assay sample, a reagent therefor, a kit therefor, a method of diagnosing cancer in digestive organs, and to a monoclonal antibody. Particularly, it relates to a method of determining human acid
BACKGROUND OF THE INVENTION
I. Field of the Invention
The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides organic arsenic compounds and methods for their use in treating cancers such as leukemia.
II. Description of Related Art
Despite progress
I. Field of the Invention
The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides organic arsenic compounds and methods for their use in treating cancers such as leukemia.
II. Description of Related Art
Despite progress in leukemia therapy, most
BACKGROUND OF THE INVENTION
I. Field of the Invention
The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides organic arsenic compounds and methods for their use in treating cancers such as leukemia.
II. Description of Related Art
Despite progress
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to the use of novel S(N-hydroxycarbamoyl) glutathione mono- and di-ester derivatives as potent cytotoxic and anti-tumorigenic agents, and to a method of treating tumorigenic diseases with these derivatives.
The present invention relates to the use of substituted acryloyl distamycin derivatives, in particular to the use of .alpha.-bromo- and .alpha.-chloroacryloyl distamycin derivatives, in the treatment of tumors associated with high levels of glutathione and/or glutathione-S-transferases family.
More
FIELD OF THE INVENTION
This invention relates to novel haloenol lactone compounds. These compounds are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. The measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The
FIELD OF THE INVENTION
This invention relates to novel haloenol lactone compounds. These compounds are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. The measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The
FIELD OF THE INVENTION
The invention relates to peptidomimetic compounds which are novel analogs of glutathione. The invention also relates to pharmaceutical compositions comprising such glutathione analogs. The novel analogs are useful as inhibitors of glutathione S-transferase, in particular of
FIELD OF THE INVENTION
This invention relates to nucleic acid and amino acid sequences of a novel glutathione s-transferase and to the use of these sequences in the diagnosis, prevention, and treatment of cancer.
BACKGROUND OF THE INVENTION
The glutathione s-transferases (GST) are a ubiquitous
FIELD OF THE INVENTION
This invention relates to nucleic acid and amino acid sequences of a novel glutathione S-transferase and to the use of these sequences in the diagnosis, prevention, and treatment of cancer.
BACKGROUND OF THE INVENTION
The glutathione S-transferases (GST) are a ubiquitous
BACKGROUND OF THE INVENTION
Nitric oxide (NO) is integral to many biological processes including the control of blood pressure, protection against microbial infection and neurotransmission. Additionally, it appears to be a potent cytotoxin to tumor cells. Among its mechanisms of action on malignant
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to the fields of enzymology, protein structure and drug screening. More specifically, the present invention relates to the use of a crystalline structure of an aldose reductase complexed with NADPH and
FIELD OF THE INVENTION
The present invention is directed to methods and compositions for treating tumors and other metastatic diseases exhibiting high tyrosinase and saccharide enzyme activity. The invention is further directed to methods and compositions for treating tumors having high tyrosinase
FIELD OF THE INVENTION
The present invention is directed to methods and compositions for treating tumors and other metastatic diseases exhibiting high tyrosinase and .beta.-glucuronidase activity. The invention is further directed to methods and compositions for treating tumors having high