glutathione/nausea

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Probiotics in Metformin Intolerant Patients With Type 2 Diabetes

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The optimal daily dose of metformin is thought to be 2000 mg, however patients with metformin intolerance cannot reach this target dose. Participate in this study are metformin intolerant. Metformin intolerant patients have been defined as those not able to be treated with the metformin daily dose

FIGHT-RP 1 Extension Study

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Kinetics of Metabolic Cofactors in NAFLD

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In 10 healthy subjects with BMI <30 kg/m2 the plasma concentrations of 4 natural compounds (nicotinamide riboside, L-carnitine, L-serine and N-acetylcystein) are measured by ultra-performance liquid chromatography-tandem mass spectrometry (UPLCMSMS) after individual and combined administration, on

Effect of Selenium on Succinylcholine-Induced POM

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Eligibility and type of the study: This prospective randomized placebo-controlled double-blind study will be conducted after approval from the Institutional Ethics Committee and obtaining written informed consent from patients scheduled for elective adult sinuscopic procedures under general

Netupitant/Palonosetron Hydrochloride and Dexamethasone With or Without Prochlorperazine or Olanzapine in Improving Chemotherapy-Induced Nausea and Vomiting in Patients With Breast Cancer

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PRIMARY OBJECTIVES: I. To determine if control of nausea at cycle 2 in participants who experienced chemotherapy-induced nausea and vomiting (CINV) at cycle 1 is improved by the addition of either prochlorperazine or olanzapine to the control arm of netupitant, palonosetron and

Opioid-Redox Study

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The process of the study, the choice of the patients, the collection and the processing of data A. Potential participants of study will be familiarized with the course of research in every detail before entering the study and after signing of an informed consent they will be examined by

Effect of Deferiprone on Oxidative-Stress and Iron-Overload in Low Risk Transfusion-Dependent MDS Patients

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INTRODUCTION 1.1 Background Myelodysplastic syndrome (MDS) is characterized by deficiencies in blood cell production that can lead to anemia, which may necessitate regular transfusions of red blood cells (RBCs) as supportive therapy. While this treatment can be life-saving, since the body has no

Prospective, Non-randomized Observational Trial of Selenium in Cardiac Surgery

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Heart Surgery on the heart-lung machine involves, inter alia, by ischemia and reperfusion, the release of reactive oxygen radicals and nitrogen oxide (NO), which damage DNA after reaction with peroxynitrite, and Lipid-/Endothelmembrane Protein. The formation and consumption of peroxynitrite can be

Induced Changes in Ventilatory Responsiveness and Altitude Exposure

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This study will determine if modulating reduction/oxidation (redox) status through a temporary increase in the blood ratio of reduced-to-oxidized glutathione (i.e., GSH/GSSG) will increase carotid body chemosensitivity and thus increase ventilation and arterial oxygen saturation (SaO2) during 32

Transdermal Absorption of Dimercaptopropane-1-Sulfonate (DMPS) and Effect on Urinary Mercury Excretion

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I. Background Information and Literature: 2,3-dimercaptopropane-1-sulfonate (DMPS) is a chelating agent that has been used for years in Europe for treatment of poisoning by metals such as mercury, arsenic, and lead. It is a water soluble analog of dimercaptopropanol (British anti-Lewisite, or BAL),

Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material

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In this study we will test the hypothesis that acetylcysteine exerts a renoprotective effect in RCIN by an antioxidant and/or renal vasodilator mechanism. We will take a structured 4-part approach, using randomised controlled cross-over studies to assess the effect of acetylcysteine on renal

High-Dose N-Acetylcysteine in Cardiac Surgery

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Background Renal impairment following cardiopulmonary bypass is common. 11.4% (1) to 42% (2) of patients with previously normal renal function show a postoperative rise in serum creatinine. While most of these patients do not require either short or long term renal replacement, the mortality of

Interaction of Cobalamin Status With Nitrous Oxide in Relation to Postoperative Cognitive Changes in the Elderly

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Study Design: - Double-blind, randomized study of elderly patients scheduled for elective surgery under general anesthesia. - Medical, cobalamin-related, and demographic information; - Blood tests of cobalamin-related metabolic status and genotyping for 4 relevant mutations; - Psychoneurologic

Effect of Glutathione on Blood Alcohol and Hangover Symptoms

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Type of Study: Double-blinded control Population: 100 males Inclusion Criteria: - Males 20-40 years - Healthy, without chronic diseases, especially must have normal hepatic function, measured by serum SGPT - No history of alcoholic allergy - Drink alcohol regularly, at least once a week - Agree to

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