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Hypolipidemic effects of gossypol in cynomolgus monkeys (Macaca fascicularis).
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The effect of gossypol acetic acid (gossypol) on plasma lipid concentrations was studied in adult male cynomolgus monkeys consuming a diet containing 0.19 mg cholesterol/Kcal. Gossypol was administered orally at 5 (n = 4) or 10 (n = 3) mg/kg/day for 6 months. A significant decrease in total plasma
A histopathologic study of the effects of gossypol on the female rat.
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The purpose of this study was to examine the tissues of female rats treated with gossypol acetic acid for morphologic evidence of an underlying mechanism of infertility. The number of estrous cycles, and body and adrenal weights were also compared. The number of estrous cycles decreased in rats
Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.
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Gossypol has demonstrated in vitro effects on cell cycle regulation and anti-tumor activity against mammary carcinoma cell lines. This Phase I/II study assesses both the effect of gossypol on cell cycle regulatory proteins in vivo and the clinical effect. Twenty women with refractory metastatic
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