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5 risultati
Influence of 5-hydroxytryptamine on the combination effect of lonidamine or gossypol and hyperthermia on Ehrlich tumour in vivo.
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An experiment was conducted using lonidamine and gossypol against Ehrlich tumour in the foot pad of CD-1 mice. These compounds alone were mild antitumour agents, but their cytotoxicity increased when they were combined with hyperthermia. The antitumor effect was further increased by
Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells.
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OBJECTIVE
Retinoblastoma is a malignant tumor of the retina usually occurring in young children. To date, the conventional treatments for retinoblastoma have been enucleation, cryotherapy, external beam radiotherapy, or chemotherapy. Most of these treatments, however, have possible side effects,
Gossypol as a toxicant in livestock.
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Many cases of gossypol toxicity have been misdiagnosed. The long-held belief that gossypol toxicity did not occur in ruminants has been a major hurdle to overcome. Field necropsies in which pulmonary congestion and edema were attributed to shipping-fever pneumonia, failure to examine the heart
The effect of gossypol and Lonidamine on electron transport in Ehrlich ascites tumor mitochondria.
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The effect of the association of gossypol and Lonidamine on the electron transport in Ehrlich ascites tumor mitochondria has been investigated by addition of drugs to isolated mitochondria. The results may be summarized as follows. (1) Low concentrations of gossypol increase the rate of oxygen
Gossypol, a hyperthermic sensitizer of HeLa cells.
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Gossypol, a polyphenolic aldehyde extracted from cotton plants, is a potent antifertility agent in humans. Since we have previously reported that several male antifertility agents including 5-thio-D-glucose and lonidamine demonstrate hyperthermic sensitizing effects in HeLa cells, we wished to
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