this arm will recieve PEG3350 in addition to standard of care

this arm will recieve only standard of care for management of hepatic encephlaopathy with ACLF

Hepatic Encephalopathy

Acute-On-Chronic Liver Failure

experimental arm will receive 2 doses of PEG3350 spaced over 12 hours after randomization to arm1. PEG as dose of 2litres (1 sachet dissolved in 2L of water) will be administered via a nasogastric tube.

PEG-3350 with Electolytes

Lactulose will be given orally (30ml QID) which shall be titrated to ensure 2-3 soft stools per day

Lactulose

Postgraduate Institute of Medical Education and Research

PEG3350 in ACLF With Hepatic Encephalopathy

Therapeutic Efficacy of Oral PEG3350 Plus Lactulose Versus Lactulose Alone in Patients of Acute on Chronic Liver Failure With Overt Hepatic Encephalopathy: A Single Blind Prospective Randomized Controlled Study

to look for any survival benefit in experimental arm at 28 days and 90 days

to look for the degree of improvement in grade of HE in both experimental arm and lactulose arm.

to extrapolate weather reduction of grade of HE correlates with reduction of ammonia levels

to analyse the difference in time to event(death) among non survivors in experimental arm

to look for any evidence of cerebral edema reduction by means of optic nerve sheath diameter

to analyse if reduction of HEresults in reduction or prevention of seizure episodes in both arms

Radha K Dhiman

Professor

participant is randomised using a table of random numbers.

Parkinson Disease

Inflammation

Rifaximin 550 MG, TWICE A DAY, FOR 7 DAYS

Rifaximin 550 MG

Shuang Ho Hospital

Modulation of Gut Microbiota by Rifaximin in PD Patients

Comparing the gut microbiota analyzed by 16sRNA with baseline

Comparing the blood level of inflammatory/infection markers (TNF-alpha, IL-6, LPS & zonulin) and exosomal alpha-synuclein

Chien Tai Hong

Doctor, Assisstant Professor, Principal Investigator

Taipei Medical University Shuang Ho Hospital

People at early stage of Parkinson's disease

Branched Chain amino acid 10 grams packet (L-Isoleucine (952 Mg), L-Leucine (1904 Mg.), L-Valine(1144 Mg). one packet at 6pm and two at 9pm.

Equinitrogenous amount of lactoalbumin 2.1 grams, and equicaloric amount with 4.0 g saccharose and 3.0 g mannitol for a total of 33.6 kcal/packet.(one packet at 6pm and two at 9pm)

Liver Cirrhoses

Branched chain amino acid 10 grams packet (L-Isoleucine (952 Mg), L-Leucine (1904 Mg.), L-Valine(1144 Mg).

Branched chain amino acid

an equinitrogenous amount of lactoalbumin 2.1 grams, and equicaloric amount with 4.0 g saccharose and 3.0 g mannitol for a total of 33.6 kcal/packet.(one packet at 6pm and two at 9pm)

Placebo

Dyanand Medical College and Hospital

Sarcopenia Improves the Muscle Mass and Muscle Strength of Patients With Liver Cirrhosis-Child C

Treatment of Sarcopenia Improves the Muscle Mass and Muscle Strength of Patients With Liver Cirrhosis- Child C: A Randomized Double Blind Control Trial

Change in CT Skeletal muscle index (cm2/m2) (i.e difference between the baseline and 3 month values)

3-month change in Hand Grip Strength (Kilogram) (calculated as the difference between the baseline and 3-month values obtained by Hand Grip Dynamometer)

3-month change in muscle performance assessed by change in Gait Velocity (m/min)

3-month event-free survival at 3 months (events including complications of Cirrhosis i.e. Hepatic encephalopathy, Ascites and edema, Variceal Hemorrhage, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome)

Change in health related quality of life measure by Short Form Health Survey (SF 36) QUESTIONNAIRE

Change in muscle performance assessed by improvement in Chair Stand.

hepatic encephalopathy/carbohydrate

PEG3350 in ACLF With Hepatic Encephalopathy

Modulation of Gut Microbiota by Rifaximin in PD Patients

Sarcopenia Improves the Muscle Mass and Muscle Strength of Patients With Liver Cirrhosis-Child C

Resting Energy Expenditure in Patients on the Waiting List for Liver Transplantation

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