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12 risultati
C5-substituted, proline-derived, macrocyclic hepatitis C serine protease inhibitors
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TECHNICAL FIELD
The present invention relates to macrocycles having activity against the hepatitis C virus (HCV) and useful in the treatment of HCV infections. More particularly, the invention relates to C5-substituted, proline-derived, macrocyclic compounds, compositions containing such compounds
Bicyclic, C5-substituted proline derivatives as inhibitors of the hepatitis C virus NS3 protease
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TECHNICAL FIELD
The present invention relates to novel bicyclic compounds having activity against the hepatitis C virus (HCV) and useful in the treatment of HCV infections. More particularly, the invention relates to bicyclic, C5-substituted proline derivatives, compositions containing such
Substituted prolines as inhibitors of hepatitis C virus NS3 serine protease
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FIELD OF THE INVENTION
The present invention relates to novel hepatitis C virus ("HCV") protease inhibitors, pharmaceutical compositions containing one or more such inhibitors, methods of preparing such inhibitors and methods of using such inhibitors to treat hepatitis C and related disorders. This
Stereomerically pure fused bicyclic proline compounds useful for preparing hepatitis C protease inhibitors
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2. TECHNICAL FIELD
The present disclosure relates to substantially stereomerically pure fused bicyclic proline compounds of structural Formulae II to VII:
##STR00002## in which A, M, M', and R.sup.5 are as described herein, to biocatalytic processes for their preparation, and to the biocatalytic
3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis C virus NS3 serine protease
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FIELD OF THE INVENTION
The present invention relates to novel hepatitis C virus ("HCV") protease inhibitors, pharmaceutical compositions containing one or more such inhibitors, methods of preparing such inhibitors and methods of using such inhibitors to treat hepatitis C and related disorders. This
Nucleic acid comprising chimeric gene derived from hepatitis C virus
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TECHNICAL FIELD
The present invention relates to a nucleic acid comprising a chimeric gene derived from hepatitis C viruses, a chimeric hepatitis C virus particle of the JFH-1 strain and a strain other than the JFH-1 strain (preferably a strain of genotype 1a, 1b, or 2a), a vector used for producing
Hepatitis C inhibitor peptide analogues
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FIELD OF THE INVENTION
The present invention relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel peptides and analogues thereof, pharmaceutical compositions containing such peptides and methods for
Proline derivatives
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BACKGROUND
Hepatitis C virus (HCV) infection is estimated to affect 170 million individuals worldwide. This disease is primarily transmitted through contaminated blood products. Although its spread has been slowed as a result of improvement in blood screening in many countries, it remains the
Macrocyclic proline derived HCV serine protease inhibitors
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JOINT RESEARCH AGREEMENT
Inventions described in this application were made by or on behalf of Enanta Pharmaceuticals, Inc. and Abbott Laboratories who are parties to a joint research agreement, that was in effect on or before the date such inventions were made and such inventions were made as a
Macrocyclic proline derived HCV serine protease inhibitors
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JOINT RESEARCH AGREEMENT
Inventions described in this application were made by or on behalf of Enanta Pharmaceuticals, Inc. and Abbott Laboratories who are parties to a joint research agreement, that was in effect on or before the date such inventions were made and such inventions were made as a
Antiviral compounds
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TECHNICAL FIELD
The invention is directed to inhibitors of viral replication. In particular, it concerns the use of compounds related to the immunosuppressant macrolide FK506 to interfere with replication.
BACKGROUND ART
The macrolide FK506, which is of the formula: ##STR1## is manufactured by
Antiviral compounds
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TECHNICAL FIELD
The invention is directed to inhibitors of viral replication. In particular, it concerns the use of compounds related to the immunosuppressant macrolide FK506 to interfere with replication.
BACKGROUND ART
The macrolide FK506, which is of the formula: ##STR1## is manufactured by
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