Infants who will receive caffeine in the delivery room.

Respiratory Distress Syndrome

Infants will receive 20 mg/kg of caffeine citrate intravenously, via the umbilical vein, or enterally, through an orogastric tube, within 10 min of birth.

Caffeine Citrate

Caffeine Treatment in in the Delivery Room

Treatment With Caffeine of Very Preterm Infant in the Delivery Room: the CAFROOM Feasibility Study

Evaluation of the number of infants in which the administration of intravenous or enteral caffeine in the delivery room will occur successfully

Evaluation of number of infants in whom caffeine will be successfully administered by intravenous versus enteral route

Number of infants in whom caffeine will be successfully administered that reached the therapeutic plasmatic range after the first dose

Comparison of caffeine blood level obtained with intravenous and enteral administration

Data will be collected in electronic sheet. These data will be available on request.

Carlo Dani

Full Professor of Pediatrics

University of Florence

A cohort of preterm infants will be given caffeine in the delivery room

Patients will be selected from Rh isoimmunized patients (positive titre of indirect coomb's test) who are scheduled to have intrauterine blood transfusion. This intrauterine blood transfusion is due to fetal anemia, and it is detected when the measurement of PSV (peak systolic velocity) of middle cerebral artery is more than 1.5 MoM (multiple of the median) according to Fetal Medicine unit of Cairo University protocol. All fetuses are free of structural and functional Fetal and echocardiographic anomaly scan.

Fetal Anemia as Antepartum Condition (Diagnosis)

Rh Incompatible Blood Transfusion Nos

Venous and arterial Doppler indices:
Middle cerebral artery (MCA) peak systolic velocity (PSV):
Umbilical Artery Pulsitility Index (PI) and Resistant Index (RI):
Ductus venosus (DV) Doppler:
Cardiac functions:
Global cardiac function evaluated by Modified Myocardial Performance Index (Mod-MPI):
Systolic cardiac function using the four-dimensional (4D) spatiotemporal imaging correlation (STIC) ultrasound technique:
Diastolic cardiac function evaluated by relationship between the maximal velocities of the E and A waveforms of ventricular filling (E/A ratio)

Mid trimesteric fetal ultrasonography

Cairo University, Faculty of Medicine, Obstetrics and Gynecology Department, Cairo Fetal Medicine Unit.

Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion

the ratio between summation of isovolumetric contraction time (ICT) + isovolumetric relaxation time (IRT) in melliseconds and ejection time (ET) in melliseconds

Fetal Hemoglobin (Hb) levels which is measured by g/dl. A blood sample is collected from umbilical vein prior to blood transfusion (Sample 1) and another blood sample (Sample 2) after blood transfusion just before withdrawing of the trnsfusion needle from umbilical vein

MCA PSV will be identified by using pulsed wave Doppler in cm/s

The relationship between the maximal velocities of the E and A waveforms of ventricular filling

National Research Center, Egypt

Cairo University

This will be a prospective study. Patients will be selected from Rh isoimmunized patients (positive titre of indirect coomb's test) who are scheduled to have intrauterine blood transfusion.Selected patients will be monitored weekly from 15 weeks gestational age till 28 weeks of gestational age.

hydrops fetalis/infiammazione

Caffeine Treatment in in the Delivery Room

Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion

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