One forearm will be treated with ointment containing Hypericum perforatum oil. Forearm (left or right) will be chosen according to randomization protocol.

Other forearm will be treated with placebo ointment. Forearm (left or right) will be chosen according to randomization protocol.

Skin Recovery in Different Human Skin Damage Models

Ointment containing Hypericum perforatum oil

Hypericum perforatum oil

Ointment containing plant oils used in Hypericum perforatum oil production and dye

Placebo

60 uL of 1% w/v sodium lauryl sulphate (SLS) will be applied to skin under occlusion by large Finn chamber for 24 hours as described in the guidelines by Standardization group of European Society of Contact Dermatitis. Procedure will be performed to specified skin sites, according to randomization protocol.

SLS induced irritation

Skin barrier disruption will be induced by tape-stripping. Procedure will be performed to specified skin sites, according to randomization protocol.

Tape-stripping

UV radiation will be used to induce skin erythema and damage. Procedure will be performed to specified skin sites, according to randomization protocol.

UV radiation

Healthy, intact skin. Procedure will be performed to specified skin sites, according to randomization protocol.

Intact skin

School of Medicine

Effects of Hypericum Perforatum Oil on Promoting Skin Recovery in Different Human Skin Damage Models

Effects of Hypericum Perforatum Oil on Promoting Skin Recovery in Different Human Skin Damage Models, Randomized Controlled Trial

Tewameter will be used to assess skin barrier function as a measurement of the water loss (g/hm2).

Corneometer will be used to estimate skin dryness. It is a relative measurement and uses arbitrary units (AU).

Mexameter will be used to assess erythema. It is a relative measurement and uses arbitrary units (AU).

Mexameter will be used to assess skin melanin content. It is a relative measurement and uses arbitrary units (AU).

University of Split, School of Medicine

Zoloft 50 mg by mouth daily for 1 week if tolerated dose may be increased to 100 mg daily for 4 months

St. John's wort 600 mg daily for 1 week. If tolerated dose may be increased to 900 mg daily for four months.

Depression

Unspecified Adult Solid Tumor, Protocol Specific

Zoloft 50 mg

St. John's wort 600 mg daily for 1 week, if tolerated. Dose may be increased to 900 mg daily for 4 months.

St. John's Wort 600 mg

Bay Area Tumor Institute

Regional Radiation Oncology Center at Rome

CCOP - Central Illinois

CCOP - Southeast Cancer Control Consortium

High Point Regional Hospital

Comprehensive Cancer Center at Wake Forest University

Sertraline Compared With Hypericum Perforatum (St.John's Wort) in Treating Depression

A Phase III Double-Blind Randomized Trial Comparing Sertraline (Zoloft) And Hypericum Perforatum (St. John's Wort) In Cancer Patients With Mild To Moderate Depression

To compare the change in depression severity in cancer patients with mild to moderate depression on sertraline and St. John's wort.

Wake Forest University Health Sciences

National Cancer Institute (NCI)

Patients receive oral placebo three times daily on days 1-14 and docetaxel IV over 1 hour on day 15.
Treatment in both groups repeats every 21 days for 2 courses in the absence of disease progression or unacceptable toxicity.
Patients are followed for new primaries and survival only.

Patients receive oral Hypericum perforatum three times daily on days 1-14 and docetaxel as in arm 1.
Treatment in both groups repeats every 21 days for 2 courses in the absence of disease progression or unacceptable toxicity.
Patients are followed for new primaries and survival only.

Patients receive docetaxel as in arm 1 and continue to receive their chronic regimen of Hypericum perforatum except on day 15.
Treatment in both groups repeats every 21 days for 2 courses in the absence of disease progression or unacceptable toxicity.
Patients are followed for new primaries and survival only.

hyperforin/hypericum

Effects of Hypericum Perforatum Oil on Promoting Skin Recovery in Different Human Skin Damage Models

Sertraline Compared With Hypericum Perforatum (St.John's Wort) in Treating Depression

Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery

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