The invention relates to a combination of heat-treated nutritional composition having a carbohydrate fraction comprising a) 5-30 wt % of one or more monosaccharides selected from galactose, ribose and mannose; b) carbohydrates capable of providing b1) sustained release glucose and b2) rapidly available glucose; c) optionally fructose; d) glucose-containing disaccharides other than maltose and sucrose; and e) optionally sugar polyols. The invention also pertains to the use of such a heat-treated nutritional composition for controlling glucose levels in blood and/or tissue, especially for preventing and/or treating diabetics, insulin-resistance, obesity, postprandial glucose response, metabolic syndrome, syndrome X, hyperglycemia, hypertriglyceridemia, hyperinsulinemia, dyslipidemia, dysfibrinolysis and/or disorders associated with major surgery or trauma.

Bouritius; Houkje

Abrahamse; Evan

Kiers; Wynette Hermina Agnes

Severijnen; Chantal

van Laere; Katrien Maria Jozefa

Hageman; Robert Johan Joseph

N.V. Nutricia

Carbohydrate fraction and use thereof for a flat postprandial glucose response

Intrauterine fetal growth restriction (IUGR) is an affliction of a disparaging spectrum, placental insufficiency being the major inciting pathology. The resultant fetal hypoglycemia is alleviated by intravenous hypertonic D-glucose 25-50% maternal supplements, by improving the V.sub.max of placental substrate transfer, as per Michaelis-Menten model. Fetal normoglycemia so restored in turn surprisingly improves fetal hypoxia, hypercapnia if any, lactic acidemia, acidosis, oliguria with/without oligohydromnios, hypertriglyceridemia, and the fetal nutrient, mineral and vitamin acquisition. The list being phenomenal can only convince an inquiring reader by a biochemical sojourn into the aquatic world of the fetus, herein described. Maternal carbohydrate predominant, essential amino acids/fatty acids rich IUGR-diet incorporating maximal amounts of vitamin and minerals are highly beneficial for attainable placental V.sub.max. Transamniotic isotonic D-glucose supplement via minimally invasive `Suprapubic extraperitonial pelvic approach` for amniotomy (Sumathi Paturu's technique) with a Subcutaneously Implanted Pregnancy Port (SIPP) catheter is the additional therapy advocated.

Paturu; Sumathi

Intrauterine fetal growth restriction--the biochemical rationale of treatment modalities including extraperitoneal transamniotic fetal supplements

hypertriglyceridemia

carbohydrate

hypertriglyceridemia/carbohydrate

Carbohydrate fraction and use thereof for a flat postprandial glucose response

Intrauterine fetal growth restriction--the biochemical rationale of treatment modalities including extraperitoneal transamniotic fetal supplements

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