hypokalemia/hypoxia

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Fentanyl-induced block of hERG channels is exacerbated by hypoxia, hypokalemia, alkalosis, and the presence of hERG1b.

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Human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (I_Kr) important for repolarization of cardiac action potentials. Drug-induced disruption of hERG channel function is a main cause of acquired long

[Bronchial asthma attack with lactic acidosis and hypokalemia in a case receiving high dose inhalation of procaterol hydrochloride].

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We report a case of bronchial asthma attack with lactic acidosis and hypokalemia in a patient receiving high-dose inhalation of procaterol hydrochloride. A 28-year-old man was transferred to our hospital because of adynamia, nausea and dyspnea. He had used inhaled procaterol hydrochloride with a

Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice.

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A 93 year-old hypertensive woman was found to have severe hypokalemia (as low as 1.3 mEq/L) and developed paralysis of the all extremities associated with metabolic alkalosis, hypoxemia, hypercapnea, extremely high levels of creatine phosphokinase (up to 9280 U/L), myoglobin and myoglobinuria

Renin-angiotensin II-aldosterone and ACTH-cortisol control during acute hypoxemia and exercise in patients with chronic obstructive pulmonary disease.

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Acute hypoxia has been reported to induce a decrease in aldosterone levels despite no change or increases in plasma renin activity and ACTH. Converting enzyme inhibition and/or mild hypokalemia have been suggested as possible mechanisms for this dissociation. We studied 15 patients with chronic

Probable fatal cardiac dysrhythmia secondary to diuretic-induced hypokalemia.

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This case study describes the investigation of the sudden, unexpected death of a young, slightly hypertensive woman. She had a previous history pf serious hypokalemic-induced cardiac dysrhythmias associated with diuretic usage. Postmortem examination revealed no anatomic cause for her death. Her

Acute and chronic hypokalemia sensitize the isolated heart to hypoxic injury.

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We examined the effects of acute and/or chronic hypokalemia on responses to 30 min of hypoxia and recovery in the isolated, perfused heart model. We found that both acute hypokalemia and chronic hypokalemia impaired contractility [expressed as maximum slope of pressure increase over time (dP/dt):

Chronic hypokalemia and intraoperative dysrhythmias.

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To investigate whether chronic hypokalemia increases the occurrence of dysrhythmias during anesthesia, the authors recorded the intraoperative electrocardiograms of normokalemic (K+ = 5.0 -3.5 mEq/l; N = 88) and chronically hypokalemic patients (K+ = 3.4 - 2.6 mEq/l; N = 62). In each patient, serum

Hypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity.

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We investigated the hypothesis that hypokalemia might induce renal injury via a mechanism that involves subtle renal injury and alterations in local vasoactive mediators that would favor sodium retention. To test this hypothesis, we conducted studies in rats with diet-induced K+ deficiency. We also

Hyperleukocytosis Complicated by Intracerebral Hemorrhage and Spurious Hypoxemia: A Case Report and Literature Review.

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We present the management of a 15-year-old girl with acute myeloid leukemia who presented with massive hyperleukocytosis and neurological deficit due to intracerebral hemorrhage. Surgical intervention was considered but ultimately not undertaken because of the presence of massive hyperleukocytosis,

Pulmonary edema occurring after isoxsuprine and dexamethasone treatment for preterm labor: Case report.

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A case of maternal pulmonary edema occurring in a patient in the 32nd week of gestation is presented. This was our first case of pulmonary edema seen during a period of five years' usage of isoxsuprine in the treatment of premature labor. The patient presented was 28 years old, gravida 2, para 1,

Severe metabolic alkalosis due to baking soda ingestion: case reports of two patients with unsuspected antacid overdose.

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Oral ingestion of baking soda (sodium bicarbonate) has been used for decades as a home remedy for acid indigestion. Excessive bicarbonate ingestion places patients at risk for a variety of metabolic derangements including metabolic alkalosis, hypokalemia, hypernatremia, and even hypoxia. The

[A case of ventricular fibrillation during emergency clipping operation for cerebral aneurysm].

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A 59 year-old woman with subarachnoid hemorrhage underwent emergency neck clipping of cerebral aneurysm. Her preoperative examination showed atrial fibrillation, pulmonary edema and hypokalemia. Ventricular fibrillation developed immediately after clipping of the aneurysm and recurred 7 times

[Acid-base disturbances in heart failure].

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Disturbance in acid-base balance is commonly observed in patients with heart failure. The most common disturbance is metabolic alkalosis combined with hypokalemia, as a result of the excessive use of loop diuretics. Occasionary, hypoxia due to pulmonary edema stimulates ventilation, resulting in

Electrolytes imbalance in saltwater near-drowning victims in the Gulf of Thailand.

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BACKGROUND Near-drowning victims in saltwater are expected to have multiple electrolytes imbalance that affected treatment outcome. There are limited data about these parameters in Thailand to guide the treatment plan. OBJECTIVE To study the characteristic of electrolytes imbalance in saltwater

[Electrolytic and electrocardiographical correlations under 7% oxygen in nitrogen in dogs (author's transl)].

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Electrolytic concentrations in plasma and electrocardiographic parameters in dogs have been studied by means of lineal and canonical correlations, after the animals have been submitted to 7% oxygen in nitrogen for three hours. At the end of hypoxia there appeared hypokalemia, increased T wave

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