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Pagina 1 a partire dal 23 risultati
Treatment of Chemotherapy and Radiotherapy Induced Oral Mucositis
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The term "mucositis" was introduced to describe inflammation of the oral mucosa induced by radiotherapy, chemotherapy and bone marrow transplantation. At present, oral mucositis is considered to be the most serious non-hematological complication of cancer treatment.
Numerous predisposing factors
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease.
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Lithium belongs to a class of kinase-targeting therapies, including the diabetes medication exenatide and the cancer medication nilotinib, that have demonstrated promise as disease-modifying therapies for Parkinson's disease (PD). Exenatide was recently shown to engage protein kinase B (Akt) and
18F-Fluciclovine PET and Multiparametric MR Imaging
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Methods:
Patients with recurrent high grade glioma diagnosed on MRI and consenting to study protocol will undergo 18F-Fluciclovine PET/CT imaging. Surgery for recurrent brain tumor will follow standard of care treatment including as complete as possible tumor resection followed by histopathological
Myo-inositol, D-chiro-inositol and Glucomannan in PCOS
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1. RATIONALE & BACKGROUND INFORMATION Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome and one of the most common female endocrine disorders, affecting 5-20% of women in reproductive age . Clinical expression is highly variable, but typically includes oligo-ovulation or anovulation,
Involvement of the Inositol-trisphosphate Receptor in Invasive or Migratory-type Breast Cancers
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Glioblastoma: Validation and Comparison Between Primary Tumor and Its Murine Model
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The presented project will focus on the evaluation of a multimodal approach comparing human GBM to paired samples of orthotopic xenografts using high resolution MRI and MRS and multidimensional molecular profiling.
20 patients with a high probability for newly diagnosed GBM based on MRI-scan ( 3
Non-surgical Periodontal Therapy and Myo-inositol in Polycystic Ovary Syndrome Women Having Chronic Periodontitis
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Polycystic Ovary Syndrome(PCOS) is a genetically complex endocrine disorder of uncertain etiology and a common cause of hyperandrogenism, anovulatory infertility, menstrual dysfunction, hirsutism, alopecia and acne. It was first reported by Stein and Leventhal in 1935. It affects 6-8% of women of
SF1126 in Recurrent or Progressive SCCHN and Mutations in PIK3CA Gene and/or PI-3 Kinase Pathway Genes
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SignalRx Pharmaceuticals has developed a pan isoform specific PI-3 inhibitor called SF1126 to treat patients with advanced or metastatic cancer. SF1126 is a conjugate that contains two components: SF1101 (the active drug) and SF1174 (an inactive tetrapeptide RGD targeting moiety)
Both components of
Graceful Lifestyle Changes Study for PCOS and Infertility
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1) Purpose
The purpose of this study is to:
1. assess if implementing lifestyle changes through instruction and coaching is as effective as standard ovulation-induction therapy,
2. evaluate if myo-inositol is an effective addition to both lifestyle intervention and standard fertility medications,
Panobinostat, Gemcitabine Hydrochloride, Busulfan, and Melphalan Before Stem Cell Transplant in Treating Patients With Refractory or Relapsed Multiple Myeloma
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PRIMARY OBJECTIVES:
I. To determine the progression-free survival (PFS) in patients with refractory or relapsed myeloma receiving panobinostat/gemcitabine hydrochloride (gemcitabine)/busulfan/melphalan (panobinostat/Gem/Bu/Mel) with autologous stem-cell transplant, either as a first or a salvage
A Phase II Evaluation of Afatinibin Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma
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Exploratory/correlative objectives: To systematically evaluate HER2/neu expression/amplification using standardized scoring criteria for both breast and gastric cancer and correlate clinical response in uterine serous carcinoma patients with HER2/neu scoring results. To correlate objective response
Dose Finding Study of BKM 120 in Combination With LH-RH Agonists and Bicalutamide in Men With Non Castrate Metastatic Prostate Cancer
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Prostate cancer is the second leading cause of cancer and the third cause of death in male. Majority of patients had local disease that is cured by local treatment. Metastases are rare at the time of diagnosis but may occur after failure of local treatment (SEER).
Recommended treatment for non
Inositol in Trichotillomania
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Pathological hair-pulling, trichotillomania, has been defined as repetitive, intentionally performed pulling that causes noticeable hair loss and results in clinically significant distress or functional impairment (1). Trichotillomania appears relatively common with an estimated prevalence between
Amatuximab for High Mesothelin Cancers
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Background:
- Amatuximab is a high-affinity monoclonal IgG antibody raised against human mesothelin.
- Mesothelin is a glycosyl-phosphatidyl inositol-linked membrane glycoprotein thought to be involved in tumor metastasis
- Mesothelin is over-expressed in many cancers
Objectives:
-The primary
Japanese BAY80-6946 Monotherapy Phase I Study
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