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Pagina 1 a partire dal 18 risultati
Isolated human inositol polyphosphate 5-phosphatase
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TECHNICAL FIELD OF THE INVENTION
The invention relates to the area of enzyme regulation. More particularly, the invention relates to the regulation of human inositol polyphosphate 5-phosphatase.
BACKGROUND OF THE INVENTION
SHC and GRB2 protein signaling molecules form a complex in response to growth
Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
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FIELD OF THE INVENTION
The present invention is directed to compositions and methods for using the mixed calcium/sodium salt of inositol-tripyrophosphate (ITPP-Ca/Na) to enhance oxygen delivery by red blood cells. ITPP-Ca/Na is an allosteric effector of hemoglobin which has the ability to cross the
Method of treating angiogenesis in tumor tissue
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The present invention relates to a method of treating angionesis in tumor tissue, which method comprises administering an isomer of inositoltrisphosphate (IP.sub.3) or a pharmaceutically acceptable salt thereof.
Even as early as the year 1900, different researchers had reported the finding of the
Combination treatment of cancer
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a US National Phase filing of PCT/EP2013/068120, filed on Sep. 2, 2013, which claims priority of 12183618.3 (EP), filed on Sep. 7, 2012, the entire disclosures of which are hereby expressly incorporated by reference.
The present invention
Inhibitors of phosphatidyl myo-inositol cycle
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to specific compounds designed to inhibit cell growth signaling. In particular, PtdIns-3-kinase anti-metabolites are rationally designed to provide compounds that inhibit cell differentiation and/or cell
Inhibitors of phosphatidyl myo-inositol cycle
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to specific compounds designed to inhibit cell growth signaling. In particular, PtdIns-3-kinase anti-metabolites are rationally designed to provide compounds that inhibit cell differentiation and/or cell
Tryptamine-based ship inhibitors for the treatment of cancer
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BACKGROUND OF THE DISCLOSURE
Colorectal cancer (CRC) is the second most common malignancy in women and the third most common malignancy in men worldwide (1). Although CRC mortality has been declining due to improvements in screening techniques and CRC treatment, it is still the second most common
Metal complex phosphatidyl-inositol-3-kinase inhibitors
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FIELD OF THE INVENTION
The present application pertains to metal complex protein kinases inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by kinase activity.
BACKGROUND OF THE INVENTION
The development of small molecules
Inhibitors of human phosphatidyl-inositol 3-kinase delta
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FIELD OF THE INVENTION
The present invention relates generally to phosphatidylinositol 3-kinase (PI3K) enzymes, and more particularly to selective inhibitors of PI3K activity and to methods of using such materials.
BACKGROUND OF THE INVENTION
Cell signaling via 3'-phosphorylated phosphoinositides
Malaria treatments
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This application is a 371 of PCT/GB93/00084 filed Jan. 1, 1993.
The present invention relates to the treatment and prevention of malaria and certain other infectious diseases, especially to materials for use in such treatment and prevention.
Malaria is caused by organisms of the genus Plasmodium
Reduction of cell proliferation and enhancement of NK-cell activity
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DESCRIPTION OF THE INVENTION 1. Technical Field of the Invention
This invention relates to compositions comprising a mixture of inositol (I) and inositol hexaphosphate (IP.sub.6) and their use in normalizing the rate of mitosis sensitive to treatment with a solution below in mammalian tissues
Neuropeptide antagonists
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This invention relates to antagonists to various receptors for neuropeptides, in particular to antagonists that are non-structural analogues of the specific mitogenic neuropeptide ligand. Neuropeptides are increasingly implicated in the control of cell proliferation.sup.1. The amphibian
Certain chemical entities, compositions and methods
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BACKGROUND OF THE INVENTION
The activity of cells can be regulated by external signals that stimulate or inhibit intracellular events. The process by which stimulatory or inhibitory signals are transmitted into and within a cell to elicit an intracellular response is referred to as signal
Phosphonates as anti-inflammation agents
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FIELD OF THE INVENTION
This invention pertains to the synthesis and use as therapeutic agents of a group of substances with a glycerol backbone or aliphatic chain structure linked to phosphonocholine, phosphinocholine, phosphonoinositol, phosphinoinositol, or other phosphorus-containing head groups.
Method for determining modulation of P110.DELTA. activity
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The invention relates to a novel lipid kinase which is part of the PI3 Kinase (PI3K) family and more specifically the invention relates to various aspects of the novel lipid kinase particularly, but not exclusively, to an identification of expression of said kinase with a view to diagnosing or
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