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Synthesis and evaluation of N-acetyl-L-tyrosine based compounds as PPARalpha selective activators.

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The development of type 2 diabetes in obese individuals is linked to lipid accumulation in non-adipose tissues. A series of N-acetyl-L-tyrosine derivatives were synthesized and evaluated for PPAR transactivation. Compounds 4d and 4f were found to show better PPARalpha transactivation as compared to

Metabolomics and correlation network analysis of follicular fluid reveals associations between L-tryptophan, L-tyrosine, and polycystic ovary syndrome

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Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder in women of reproductive age. Some studies have investigated metabolic alterations in plasma and follicular fluid (FF) from PCOS patients, but they did not control for obesity or insulin resistance (IR); additionally,

The Marine Seagrass Halophila stipulacea as a Source of Bioactive Metabolites against Obesity and Biofouling.

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Marine organisms, including seagrasses, are important sources of biologically active molecules for the treatment of human diseases. In this study, organic extracts of the marine seagrass Halophila stipulacea obtained by different polarities from leaves (L) and stems (S) (hexane [HL, HS],

Integrated omics analysis reveals the alteration of gut microbe-metabolites in obese adults

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Obesity, a risk to health, is a global problem in modern society. The prevalence of obesity was approximately 13% among world's adult population. Recently, several reports suggested that the interference of gut microbiota composition and function is associated with metabolic disorders, including

Short-term infusion of interleukin-6 does not induce insulin resistance in vivo or impair insulin signalling in rats.

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OBJECTIVE Interleukin-6 has been implicated in the insulin resistance associated with obesity and impaired glucose tolerance. Previous studies in vitro have shown that IL-6 rapidly (1-2 h) impairs cellular insulin signalling and action through an increased expression of suppressor of cytokine

The pleiotropic functions of peroxisome proliferator-activated receptor gamma.

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Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds that induce peroxisome proliferation. PPARgamma is the best characterized of the PPARs. The heterodimer of PPARgamma with the retinoid X receptor (RXR)

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