The infected group will be classified according to the severity whether mild ,moderate or severe

This group either exposed and not infected .

Biological sample will take for the following analysis 1. Routine diagnostic analysis Routine Laboratory testing includes complete blood picture (CBC), C-reactive protein (CRP), liver function tests, Blood sugar, serum creatinine 2. Routine molecular diagnostic analysis Routine molecular Laboratory testing includes Real-time PCR Detection for SARS-COV 2 3. Laboratory investigation for candidate gene i. Nucleic Acid Extraction from peripheral blood: the first step will include High-quality total nucleic acid extraction covering DNA, RNA, non-coding RNA, and Micro RNA ii. Allelic discrimination using ABI 7500 real-time PCR. The host DNA will be genotyped for candidate genes using TaqMan® SNP genotyping assays

Genetic Predisposition to Disease

Mansoura Faculty of Medicine

Immunogenetics Predictors With COVID-19

Various Molecular Markers With Predictive and Prognostic Significance in COVID-19 Outcome

To assess genetic mutation via detection of genetic polymorphisms of ACE2 in patients and control to detect what alleles will be associated with the susceptibility to COVID-19 and what alleles will be associated with clearance or protection from infections. using allelic discrimination SSCP (i.e Real-time PCR and genetic sequencer).

Mahmoud Elbendary

Professor of Tropical Medicine and Hepatogastroenterology

Mansoura University

Participants will receive usual care from their treating neurologist

Participants will be trained via videos from a three day in-person seminar that teaches the public about the use of a therapeutic diet and lifestyle to reduce multiple sclerosis related fatigue and improve quality of life.

Clinically Isolated Syndrome

Relapsing Remitting Multiple Sclerosis

Educational videos, 4 individual support calls and monthly support group meetings conducted via an internet based audio/ video conference platform. Patients will be trained on a low lectin modified paleolithic diet; breathing meditation practice, and body weight strengthening

Therapeutic diet and lifestyle

University of Iowa

Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis

Composite scores for physical health subscales

Composite scores for mental health subscales

The number of seconds it takes to walk 25 feet

Survey asking about mood and daily activities. Change in anxiety score for the hospital anxiety and depression scale score based on the responses.

Survey asking about mood and daily activities. Change in depress score for the hospital anxiety and depression scale score based on the responses.

lectin/fatica

Immunogenetics Predictors With COVID-19

Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis

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