lentinan/cancro

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Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers.

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BACKGROUND Recent studies demonstrated that patients with advanced cancer may have impaired cell-mediated immunity caused by an imbalance between Th1 and Th2 responses. We evaluated the ability of lentinan (LNT) to modulate Th1 and Th2 responses in patients with digestive cancers. METHODS Peripheral

Effect of lentinan on tumor growth in murine allogeneic and syngeneic hosts.

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The effect of lentinan on retardation and regression of transplanted tumors was analysed in allogeneic and syngeneic tumor-host systems. The effect of lentinan treatment was most variable in random-bred Swiss albino mice bearing sarcoma 180. With inbred host strains, it was most effective in A/PH

[Provision for adverse effect of S-1 containing chemotherapy in patients with advanced digestive cancer--combination with superfine dispersed lentinan].

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OBJECTIVE Recently, in drug therapy for patients with advanced digestive cancer, S-1 (tegafur x gimeracil x oteracil potassium) alone or S-1 combined with other chemotherapeutic agents (S-1+alpha) is prescribed. However, many patients are often forced to give up long-term S-1 treatment owing to high

[Cumulative effects of lentinan and endocrine therapy on the growth of DMBA-induced mammary tumor in rats].

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The cumulative effects of Lentinan and endocrine therapy on the growth of DMBA (7, 12-dimethyl benzanthracene)-induced mammary tumors of rats were studied. Multiple injection of Lentinan alone resulted in a slight degree of regression of the tumor growth, when administered to rats bearing mammary

[Studies on usefulness of postoperative adjuvant chemotherapy with lentinan in patients with gastrointestinal cancer].

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The usefulness of Lentinan, as an agent for postoperative adjuvant therapy, was investigated in patients with gastrointestinal cancer. Sixty-one patients were classified into three stages by a degree of advance for cancer (Stage II, III, IV). Furthermore, each group was put into the control group (C

Clinical efficacy of lentinan on patients with stomach cancer: end point results of a four-year follow-up survey.

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End-point results of a 4-yr followup survey and a randomized control trial of lentinan (LNT) on patients with advanced or recurrent stomach cancer have been investigated in order to evaluate the clinical efficacy of LNT in combination with chemotherapeutic agent tegafur (FT). Eligible (68) patients

[Clinical observation of thermotherapy combined with thoracic injection of lentinan in treatment of cancerous hydrothorax of patients with lung cancer].

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OBJECTIVE To study the therapeutic effect and mechanism of thermotherapy combined with thoracic injection of lentinan in treatment of cancerous hydrothorax (CH) in patients with lung cancer. METHODS Sixty lung cancer patients complicated with CH were randomly assigned to the observation group and

[Effects of lentinan in advanced or recurrent cases of gastric, colorectal, and breast cancer].

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In order to evaluate clinical efficacy of Lentinan (LNT), a purified polysaccharide extracted from Lentinus edodes, randomized controlled studies with envelope method have been conducted on the patients with advanced or recurrent, stomach, colo-rectal and breast cancer. Administration condition of

Lentinan-functionalized selenium nanosystems with high permeability infiltrate solid tumors by enhancing transcellular transport

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The delivery of nanomedicines into internal areas of solid tumors is a great challenge for the design of chemotherapeutic drugs and the realization of their successful application. Herein, we synthesized stable and efficient selenium nanoparticles (SeNPs) with an ideal size and a transcellular

Lentinan inhibits tumor angiogenesis via interferon γ and in a T cell independent manner.

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BACKGROUND Antiangiogenic agents are commonly used in lung and colon cancer treatments, however, rapid development of drug resistance limits their efficacy. METHODS Lentinan (LNT) is a biologically active compound extracted from Lentinus edodes. The effects of LNT on tumor angiogenesis were

Effects of tumor-specific antigen induced by lentinan on murine H22 hepatocellular carcinoma immunoprophylaxis.

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OBJECTIVE Hepatocellular carcinoma (HCC) is one of the most prevalent tumor types and the third most common form of morbidity in cancer-related deaths worldwide. Lentinan isolated from Lentinus edodes, is known to be a biologically active macromolecule with extremely strong activation of the human

Lentinan reduces tumor progression by enhancing gemcitabine chemotherapy in urothelial bladder cancer.

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It has been shown that chemotherapy has limited antitumor activity against advanced urothelial bladder cancer (UBC). Consequently, there is an urgent need to develop effective therapeutic methods for patients with advanced UBC. In the present study, the inhibitory effects of lentinan alone,

Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China.

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Lentinula edodes has been used to improve general health for thousands of years in Asia. It is the second largest cultivated and the most popular edible mushroom in the world known as "Xianggu" in China and "Shiitake" in Japan. Lentinan is a polysaccharide extracted from

Combined effect of cyclocytidine and lentinan of spontaneous mammary tumors in mice.

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Cytotoxic cytidine analog, cyclocytidine, and antitumor immunopotentiator, lentinan, offered an opportunity of testing the effect of combined modality of cytocidal agent and immunopotentiator on spontaneous mammary tumors of mice. Lentinan did not improve the therapeutic effect of cyclocytidine; it

Lentinan in-situ coated tungsten oxide nanorods as a nanotherapeutic agent for low power density photothermal cancer therapy.

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Development of high photothermal performance and biocompatible nanotherapeutic agents is of great importance for photothermal cancer treatment. In this paper, we have developed lentinan decorated tungsten oxide nanorods (W₁₈O₄₉@LTN NRs) via a mild one-step solvothermal route.

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