Peers (community women in leading roles) training other women in the wetting method for safe processing of cassava in a non-inferiority intervention trial.

Specialists (nutritionists) training other women in the wetting method for safe processing of cassava in a non-inferiority intervention trial..

Neurotoxicity Syndrome, Cassava

Neurotoxicity Syndrome, Cyanate

Neurotoxicity Syndrome, Cyanide

Neurotoxicity Syndrome, Thiocyanate

The intervention will implement the WTM cassava processing technique in participating households. Twenty women (in leading roles) will be our principal candidates to serve as peer trainers. Together with a 20 community health worker specialists, these women will be trained in the WTM technique by the Kinshasa team of community health workers who are experts in the WTM method. Those who master the technique will then be certified as trainers to train and support other small groups of other mothers throughout a two-year period in the implementation of the WTM for the safer processing of food for their families. Both the community health worker specialists and trained women (prospective trainers) would have to be able to bring the cassava cyanogenic content to the lowest achievable level, which must be < 10 ppm as per the recommendations of the World Health Organization.

Non Inferiority WTM Interventional Trial

INRB

Cassava Intervention Project

Toxicodietary and Genetic Determinants of Susceptibility to Neurodegeneration

Urinary concentrations of thiocyanate (U-SCN)

Kaufman Assessment Battery for Children (KABC-II) for cognition testing score

Motor proficiency Bruininks/Oseretsky Testing (BOT-2) score

Desire Tshala-Katumbay

Head Complex Morbidity Unit

Ministry of Public Health, Democratic Republic of the Congo

National Institutes of Health (NIH)

Oregon Health and Science University

Michigan State University

University of Kinshasa

National Institute of Environmental Health Sciences (NIEHS)

We will implement a novel cassava processing method (wetting method, WTM) that safely removes cyanogenic compounds from cassava flour prior to human consumption in a stratified village-cluster randomized non-inferiority trial so as to compare the effectiveness of a peer-led intervention (Arm 1 = women training other women in the WTM) with that by community-health worker specialists (Arm 2= specialist led intervention arm)

Supplement of flaxseed powder (60 g/day)during 12 weeks

Placebo powder supplement 60 g/day during 12 weeks

Flaxseed oil 30 ml/day (10 g ALA)during 12 weeks

Safflower oil 30 ml/day (no ALA) during 12 weeks

manihot esculenta/albumina

Cassava Intervention Project

Use of Flaxseed(Alpha Linolenic Acid) Powder in Morbidly Obese Patients With Systemic Inflammation

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