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Pagina 1 a partire dal 202 risultati
Intracoronary hyperosmotic mannitol during reperfusion does not affect infarct size in ischemic, reperfused porcine hearts.
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We investigated the effect of reperfusion with hyperosmotic mannitol on the infarct size in porcine hearts. The distal half of the left anterior descending coronary artery was occluded in each of 21 anesthetized pigs for 75 min and was reperfused for 2 h. During reperfusion mannitol (1075 mosmol/kg)
Accumulated mannitol and aggravated cerebral edema in a rat model of middle cerebral artery infarction.
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OBJECTIVE
Repeated administration of mannitol in the setting of large hemispheric infarction is a controversial and poorly defined therapeutic intervention. This study was performed to examine the effects of multiple-dose mannitol on a brain edema after large hemispheric infarction.
METHODS
A middle
Failure of mannitol to reduce myocardial infarct size in the baboon.
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OBJECTIVE
The aim was to determine whether mannitol, previously shown to have several myocardial protective properties, could reduce the myocardial infarct size after coronary occlusion in the baboon.
METHODS
Anaesthetised baboons underwent a 2 h transient coronary artery occlusion. Each was
The effects of mannitol on cerebral edema after large hemispheric cerebral infarct.
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OBJECTIVE
To evaluate the effect of a single large dose of mannitol on midline tissue shifts after a large cerebral infarction.
BACKGROUND
Theoretically, mannitol use in the largest cerebral infarctions may preferentially shrink noninfarcted cerebral tissue, thereby aggravating midline tissue shifts
Experimental cerebral infarction. Part 3: Protective effect of mannitol in thalamic infarction in dogs.
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Whether or not mannitol can prevent infarctions in ischemic brain tissues was investigated utilizing the thalamic infarction model in dogs. Twenty dogs were divided into equal control and mannitol treatment groups. Temporary 4 vessel clipping for 60 minutes was adopted as the standard procedure for
Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction.
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OBJECTIVE
Repeated use of mannitol in the setting of ischemic infarction is a controversial and poorly defined therapeutic intervention. The purpose of this study was to examine the effects of repeated mannitol infusions on brain water content and tissue pressure in a well-defined rat model of focal
Recirculation in the acute period of cerebral infarction: brain swelling and its suppression using mannitol.
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Using the incomplete cerebral hemisphere infarction model in dogs, observations were made on the effect of 20% mannitol on brain swelling in groups of experimental animals following recirculation. In dogs undergoing 2-hour occlusion, mannitol clearly suppresses subsequent swelling; but after 6-hour
[Peri-infarct zone and the effect of mannitol on it].
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Apart from clinical examination, blood enzyme activity was measured and ST intervals recorded on electrocardiotopograms (ECTG) from 35 leads in 56 patients (40 males and 16 females) with acute transmural anterior myocardial infarction. The osmotic diuretic mannitol was administered to 21 patients.
[The effect of mannitol in preventing the development of cerebral infarction--an electron microscopical investigation (author's transl)].
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We have undertaken an electron microscopical investigation of the effects of mannitol on the development of cerebral infarction using an experimental model for thalamic infarction in dogs. 1) It was found that administration of 20% mannitol (2 g/kg) prior to arterial occlusion had significantly
[Experimental cerebral infarction.--Part 3: The protective effect of mannitol in thalamus infarction in dogs (author's transl)].
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One day during an aneurysm surgery under the preoperative administration of mannitol, the feeding artery was accidentally occluded temporarily. Since then, investigation on whether or not mannitol can prevent infarctions in ischemic brain tissues have been carried out utilizing the thalamus
[The protective effect of mannitol and artificial blood (perfluorochemicals) on hemorrhagic infarction -- experimental study (author's transl)].
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It has previously been thought difficult to produce hemorrhagic infarction in animals. Using the thalamic infarction model in the dog, the production of hemorrhagic infarction can be achieved consistently. In this study, the protective effect of mannitol and/or artificial blood (perfluorochemicals)
Transcranial Doppler sonography monitors cerebral blood flow of mannitol-treated patients with acute large hemispheric infarction.
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OBJECTIVE
To evaluate the effect of mannitol at different doses (125 ml and 250 ml) by transcranial Doppler (TCD) sonography in patients with acute large hemispheric infarction.
METHODS
33 patients with acute large hemispheric infarction were enrolled, and the systolic peak velocity (Vs), end of
Mild hypothermia, hypertension, and mannitol are protective against infarction during experimental intracranial temporary vessel occlusion.
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A rabbit model of focal temporary ischemia was used to test the protection provided by mild hypothermia, hypertension, mannitol and the combination of the three methods. Twenty-four New Zealand White rabbits were divided into five groups as follows: a control group, a hypertension group (mean
[Development of new methods in suppressing brain infarction--combined administration of mannitol and perfluorochemicals (author's transl)].
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Various therapeutic methods have been attempted for cerebral infarction, but the development of more effective methods is still awaited. We have investigations of the effect of mannitol in preventing the development of cerebral infarction and have reported it effects in clinical cases of operated
[Development of new methods in suppressing brain infarction--combined administration of mannitol and perfluorochemicals (author's transl)].
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Various therapeutic methods have been attempted for cerebral infarction, but the development of more effective methods is still awaited. We have investigations of the effect of mannitol in preventing the development of cerebral infarction and have reported it effects in clinical cases of operated
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