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neurogenic inflammation/cefalea
Il collegamento viene salvato negli appunti
Pagina 1 a partire dal 20 risultati
Therapeutic agents for the treatment of migraine
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FIELD OF THE INVENTION
The present invention relates to novel small molecule antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment
Substituted imidazo[1,5-a]pyrazines as CGRP receptor antagonists
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
CGRP receptor antagonist
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the compound (R)--N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperaz- in-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-- carboxamide (Compound I or the compound of formula I), including
Modulation of substance P by compounds containing calcium sulfate and methods relating thereto
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TECHNICAL FIELD
The present invention relates generally to a method of modulating substance P by compounds containing calcium sulfate, particularly syngenite, gorgeyite and gypsum, and more specifically, to the synthesis of such compounds as well as their use to treat a variety of conditions
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
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FIELD OF THE DISCLOSURE
The present disclosure relates to nutritional supplements. Specifically, the present disclosure relates to nutritional supplements used to treat and/or prevent inflammation and disease states and conditions resulting from inflammation.
BACKGROUND
The human diet has been known
CGRP receptor antagonists
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BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
CGRP receptor antagonists
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
CGRP receptor antagonists
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
CGRP receptor antagonists
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP
Constrained compounds as CGRP-receptor antagonists
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BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Constrained compounds as CGRP-receptor antagonists
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Constrained compounds as CGRP-receptor antagonists
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Constrained compounds as CGRP-receptor antagonists
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Constrained compounds as CGRP-receptor antagonists
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
Calcitonin gene-related peptide (CGRP) is a naturally occurring 37-amino-acid peptide first identified in 1982 (Amara, S. G. et al, Science 1982, 298, 240-244). Two forms of the peptide are expressed (.alpha.CGRP and .beta.CGRP) which differ by one and three amino acids
Calcitonin gene related peptide receptor antagonists
Solo gli utenti registrati possono tradurre articoli
Entra registrati
FIELD OF THE INVENTION
The present invention relates to novel small molecule antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment
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