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neurogenic inflammation/nausea
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14 risultati
Symptomatology and pathogenesis of migraine.
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Migraine is a paroxysmal disorder of which headache is the central symptom. The headache is generally so intense that it is associated with other symptoms, such as nausea, vomiting, photo- and phonophobia. In so-called classic migraine or migraine with aura, the headache is preceded by transient
Naratriptan.
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Naratriptan is a selective 5-HT(1B/1D) receptor agonist, with a high affinity at the 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor subtypes. Naratriptan contracts a number of large isolated cerebral arteries from several species, and has little contractile effect on peripheral blood vessels. It has an
Alliaceous migraines.
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OBJECTIVE
To report a migraineur with osmophobia and trigger to garlic and onion aroma.
BACKGROUND
While odors serve as a trigger in 70% of migraineurs, alliaceous aromas have been described only rarely. Furthermore, nor has more than one type of alliaceous odor acted as a trigger in the same
Headache and Methemoglobinemia.
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Pharmacological synergy: the next frontier on therapeutic advancement for migraine.
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The burden of migraine significantly impacts the individual sufferer, their families, the workplace, and society. The World Health Organization has identified migraine as an urgent public health priority and has initiated a global initiative to reduce the burden of migraine. Underlying the World
Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew).
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Activation of vanilloid receptors has commonly been used to facilitate neurogenic inflammation and plasma exudation to model components of the pathogenesis of migraine; however, these studies have been performed mainly in species lacking the emetic reflex. In the present studies, therefore, we used
Migraine-like headache in a patient with complement 1 inhibitor deficient hereditary angioedema.
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We report on an angioedema patient with a genetic defect in complement 1 inhibitor, manifesting migraine-like episodes of headache, effective prophylaxis with Danazol, and triptan for a treatment of acute clinical episode. The patient was 44-yr-old Korean man with abdominal pain and headache, who
Periodontal disease as a potential factor of migraine chronification.
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Migraine is a hereditary constitutional base disorder, which is characterized by recurrent episodes of headache pulsatile characteristics associated with photophobia/phonophobia, nausea and/or vomiting. The main complication in migraine is the chronicity of the process, now recognized as a chronic
Facial presentations of primary headache disorders.
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Background Many patients with mid-face or lower face craniofacial pain are diagnosed, based on accompanying signs and symptoms and features other than location, as either atypical migraines or atypical TACs. Distinguishing features of headache disorders as a cause of facial pain include the temporal
Pathogenesis and clinical and economic consequences of postoperative ileus.
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Postoperative ileus (POI) occurs frequently in patients undergoing major abdominal surgery; and only recently has there been renewed interest in understanding the pathogenesis, etiology, clinical manifestations, and clinical and economic consequences related to POI. This interest has been spurred by
Biological and Pharmacological Aspects of the NK1-Receptor.
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The neurokinin 1 receptor (NK-1R) is the main receptor for the tachykinin family of peptides. Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is associated with multiple processes: hematopoiesis, wound healing, microvasculature permeability, neurogenic
Emerging pharmacologic options for treating postoperative ileus.
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OBJECTIVE
Characteristics of the ideal drug therapy for postoperative ileus (POI); the pharmacology, efficacy, and safety of currently available nonselective opioid antagonists and the new peripherally selective opioid antagonists methylnaltrexone and alvimopan for the treatment of POI; and
Pathogenesis and clinical and economic consequences of postoperative ileus.
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OBJECTIVE
The pathogenesis, etiology, clinical manifestations, and clinical and economic consequences of postoperative ileus (POI) in patients undergoing major abdominal surgery; the estimated prevalence of POI; the potential cost savings from efforts to shorten hospital length of stay (LOS); and
Substance P and the Neurokinin-1 Receptor: The New CRF.
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Substance P (SP) is an 11-amino acid neuropeptide of the tachykinin family that preferentially activates the neurokinin-1 receptor (NK1R). First isolated 85 years ago and sequenced 40 years later, SP has been extensively studied. Early studies identified a role for SP and the NK1R in contraction of
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