Twelve patients found to be colonized with C. difficile will undergo twice a day potato starch supplementation.

Clostridium Difficile

Hematologic Diseases

Potato starch will be given twice a day for up to 14 days, discharge, or death, whichever occurs first.

Potato starch

Medical College of Wisconsin

Oligosaccharide for Cdiff(+) Heme-onc Patients

Oligosaccharide Supplementation Among Hematology-Oncology Clostridium Difficile Colonized Patients

Samples will be collected twice a week (4-5 times during supplementation) and one time at day 21 or discharge, whichever happens first.

Patients will be provided with a diary in which they will document compliance with oligosaccharide intake. It is anticipated ≥70% of intended doses to be fully administered by the patient.

It is expected ≥50% of stool samples to be correctly collected and processed.

Stool samples collected for diagnosis and any additional stool collections will be thawed in batches and one cc aliquot will be extracted refreezing the remaining sample at -80 degrees F. One cc aliquot will then be divided into 4 sub-samples of equal volume and with the same unique identifier. This identifier will be able to chronologically cluster samples by each unique patient. A sample will be used for C. difficile qPCR quantitative determination.

Sub-sample of stool from diagnosis, and additional stool collections will be used for 16S ribosomal ribonucleic acid gene sequencing to determine the microbiome community structure

Siliva Munoz-Price

Professor

Water Intervention: In one of the 3 cycling trials, participants will receive only water and no carbohydrate supplementation during the 2 hour cycling challenge.

Carbohydrate Gel Intervention: In one of the 3 cycling trials, participants will receive carbohydrate supplementation in the form of commercially available gels (15g every 15 minutes) during the 2 hour cycling challenge.

Potatoes Intervention: In one of the 3 cycling trials, participants will receive carbohydrate supplementation in the form of pureed russet potato (15g every 15 minutes) during the 2 hour cycling challenge.

Exercise Performance

Pureed russet potatoes will be used as a carbohydrate supplement for participants during one of the three cycling challenges.

Potatoes

Commercially available PowerBar PowerGel will be used for the carbohydrate gel condition during one of the three cycling challenges.

Carbohydrate Gel

Water will be used as a control during one of the three cycling challenges (participants will not receive any carbohydrate supplementation).

Water

Freer Hall

Potato Ingestion and Time-trial Performance

Ingestion of Potatoes as a Nutritional Strategy to Improve Cycling Time-trial Performance in Endurance Trained Cyclists

Comparison of time trial performance times between potatoes and sports gel conditions to determine effectiveness of potatoes as an ergogenic aid.

oligosaccharide/solanum tuberosum

Oligosaccharide for Cdiff(+) Heme-onc Patients

Potato Ingestion and Time-trial Performance

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