Osteoarthritis / protease

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which inhibit cysteine proteases of

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to C.sub.1-6alkyl-4-amino-azepan-3-one protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which inhibit cysteine

Protease inhibitors

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This is a 371 of International Application PCT/US01/07094, filed Mar. 7, 2001, which claims benefit from the following U.S. Provisional Applications: 60/191,000 filed Mar. 21, 2000; 60/206,341 filed May 23, 2000; 60/211,759 filed Jun. 14, 2000; and 60/217,445 filed Jul. 10, 2000. FIELD OF THE

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Nanoparticle sensor for measuring protease activity and method for manufacturing the same

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CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a 35 U.S.C. .sctn..sctn.371 national phase conversion of PCT/KR2009/004794, filed Aug. 27, 2009, which claims priority of Korean Patent Application No. 10-2008-0085497, filed Aug. 29, 2008. The PCT International Application was

Carbohydrazide protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Carbohydrazide-protease inhibitors

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FIELD OF THE INVENTION This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which

Blockade of inflammatory proteases with cyclic peptides

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FIELD OF THE INVENTION This invention relates to the use of cyclic peptides for modulating cytokine activity, including signaling and inflammatory pathways, in various diseases. More particularly, cyclic peptides possess hereto unknown biological activities, such as inhibition of sheddases and other

Method to diagnose and treat degenerative joint disease

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REFERENCES AND INCORPORATION BY REFERENCE Complete bibliographic citations for the references cited herein are contained in a section titled "REFERENCES," immediately preceding the claims. All of the documents listed in the "REFERENCES" section are incorporated herein. FIELD OF THE INVENTION The

Compounds for inhibition of MMP13-substrate interactions and methods of use thereof to treat osteoarthritis and cartilage degeneration

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SEQUENCE LISTING A sequence listing submitted in computer readable format is hereby incorporated by reference. The computer readable file is named P224717sequencelist_ST25.txt, was created on Mar. 25, 2013, and contains 260 kilobytes. A supplementary sequence listing, submitted in computer readable

Protease inhibitors

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FIELD OF THE INVENTION This invention relates to inhibitors of cysteine proteases, especially those of the papain superfamily. The invention provides novel compounds useful in the prophylaxis or treatment of disorders stemming from misbalance of physiological proteases such as cathepsin

Protease inhibitors

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FIELD OF THE INVENTION This invention relates to inhibitors of cysteine proteases, especially those of the papain superfamily. The invention provides novel compounds useful in the prophylaxis or treatment of disorders stemming from misbalance of physiological proteases such as cathepsin

osteoarthritis/protease

Protease inhibitors

Protease inhibitors

Protease inhibitors

Protease inhibitors

Protease inhibitors

Protease inhibitors

Protease inhibitors

Nanoparticle sensor for measuring protease activity and method for manufacturing the same

Carbohydrazide protease inhibitors

Carbohydrazide-protease inhibitors

Blockade of inflammatory proteases with cyclic peptides

Method to diagnose and treat degenerative joint disease

Compounds for inhibition of MMP13-substrate interactions and methods of use thereof to treat osteoarthritis and cartilage degeneration

Protease inhibitors

Protease inhibitors

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