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Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies

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BACKGROUND Recent investigations have shown that mutations in epigenetic regulators are common, both in the apparently normal hematopoiesis of the elderly and in patients (pts) with myeloid cancers. It was long anticipated that DNA methylation was a permanent silencing mark, but with the discovery

Siltuximab in Schizophrenia

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A pathophysiological role for inflammation in schizophrenia has been one of the more enduring findings in the field. Recently, increased understanding of complex interactions between inflammation and the brain in other chronic diseases has better informed this relationship in schizophrenia. Several

Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine

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After identification and trial entry, we will complete intake questionnaire to determine what type of vestibular migraine category the patients qualify for, a standard of care office visit with history and physical (Standard of Care) to review symptoms and previous treatment, patients height and

Intestinal Decontamination With Rifaximin. The Inflammatory and Circulatory State in Patients With Cirrhosis

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Background: Ascites is a frequent complication of cirrhosis, occurring in 50% of patients and is associated with 50 % mortality in two years. Bacterial infections in patients with cirrhosis are frequent during hospitalization and is an important precipitating event for the development of renal

An Open-Label Trial of Tocilizumab in Schizophrenia

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Schizophrenia is a chronic, debilitating disorder with life-long consequences on affected individuals and families. Schizophrenia is also associated with impaired cognition or thinking, which persists despite currently available treatments, and is an important determinant of quality of life and

Lesinurad Monotherapy in Gout Subjects Intolerant to Xanthine Oxidase Inhibitors

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Allopurinol is the standard of care for the treatment of gout. In practice, approximately 20% of patients report side effects with allopurinol and 5% discontinue allopurinol due to side effects. Allopurinol can cause gastrointestinal intolerance, such as nausea and diarrhea, which appears to be

A Study of Sertraline to Prevent PTSD

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RESEARCH DESIGN AND METHODS 1. SPECIFIC AIM 1: To assess the efficacy of sertraline in preventing posttraumatic stress disorder in children aged 6-20 after a burn, injury or reconstructive surgery following a burn injury. 2. SPECIFIC AIM 2: To assess the efficacy of sertraline in preventing

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