A5297 was a Phase I/II, open-label, proof of concept, two-step, two-arm, randomized controlled clinical trial (RCT) to test the superiority of lopinavir/ritonavir (LPV/r)-based antiretroviral therapy (ART) to non-nucleoside reverse transcriptase (nNRTI)-based ART for clearance of Plasmodium
Study Design: VRC 312 is the second study of the PfSPZ Vaccine and the first study to evaluate intravenous (IV) administration of this vaccine. The study is designed as an openlabel evaluation of the safety, tolerability, immunogenicity and protective efficacy of the vaccine at successively higher