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Pagina 1 a partire dal 408 risultati
Fused amino pyridines for the treatment of brain tumors
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BACKGROUND OF THE INVENTION
Despite scientific advances in understanding the causes and treatment of human malignancy, a persistent challenge facing basic and clinical investigators is how to adequately treat primary and metastatic brain tumors. The blood-brain barrier is a physiologic obstruction
Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines
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FIELD OF THE INVENTION
The invention relates to 5-acyl-6,7-dihydrothieno[3,2-c]pyridines that are useful for treating pancreatic cancer and other types of cancers that are associated with aberrant expression of Hedgehog proteins.
BACKGROUND OF THE INVENTION
Pancreatic cancer is the fourth most
Treatment of pancreatic and related cancers with 5-acyl-6,7-Dihydrothieno[3,2-C]pyridines
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FIELD OF THE INVENTION
The invention relates to 5-acyl-6,7-dihydrothieno[3,2-c]pyridines that are useful for treating pancreatic cancer and other types of cancers that are associated with aberrant expression of Hedgehog proteins.
BACKGROUND OF THE INVENTION
Pancreatic cancer is the fourth most
Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines
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FIELD OF THE INVENTION
The invention relates to 5-acyl-6,7-dihydrothieno[3,2-c]pyridines that are useful for treating pancreatic cancer and other types of cancers that are associated with aberrant expression of Hedgehog proteins.
BACKGROUND OF THE INVENTION
Pancreatic cancer is the fourth most
Substituted pyridines and pyrimidines and their use in treatment of cancer
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FIELD OF THE INVENTION
This invention is in the field of pharmaceutical agents and specifically relates to compounds, compositions, uses and methods for treating cancer.
BACKGROUND OF THE INVENTION
Protein kinases represent a large family of proteins which play a central role in the regulation of a
Potentiation of cancer chemotherapy by 7-(2, 5-dihydro-4-imidazo [1, 2-A] pyridine-3-yl-2,5-Dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4 tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo [3,2,1-jk] [1,4] benzodiazepine
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BACKGROUND OF THE INVENTION
The efficacy of any cancer chemotherapy is limited by the sensitivity of specific cancers to a particular treatment. Even when a cancer is responsive to a particular chemotherapy, acute and chronic toxic effects associated with the chemotherapy often force a reduction in
Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture
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FIELD OF THE INVENTION
This invention relates to the manufacture of novel chemical compounds which have biological activity, particularly to novel chemical compounds that are cytotoxic against colon cancer cells and colon cancer cell lines.
BACKGROUND OF THE INVENTION
Cancer is considered to be the
Imidazo[1,2-a]pyridine compounds for use in treating cancer
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FIELD OF THE INVENTION
The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
SUMMARY OF THE INVENTION
According to a first aspect of the invention
Substituted pyrrolo[2,3-b]pyridines for treating cancer or inflammatory diseases
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BACKGROUND
Field
The present disclosure relates to new substituted pyrrolopyridine and pyrrolopyrazine compounds and compositions, and their application as pharmaceuticals for the treatment of disease. Methods of modulation of TAK activity in a human or animal subject are also provided for the
Potentiation of cancer chemotherapy by 7-(2, 5-dihydro-4-imidazo [1, 2-a] pyridine-3-yl-2,5-dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4 tetrahydro -2-(1-piperidinyl-carbonyl)-pyrrolo [3,2,1-jk] [1,4] benzodiazepine
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BACKGROUND OF THE INVENTION
The efficacy of any cancer chemotherapy is limited by the sensitivity of specific cancers to a particular treatment. Even when a cancer is responsive to a particular chemotherapy, acute and chronic toxic effects associated with the chemotherapy often force a reduction in
Methods of treating cancer with a thieno[3,2-C]pyridine
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FIELD OF THE INVENTION
The present invention relates to crystalline forms of N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-- 3-yl}phenyl)-N'-(3-fluorophenyl)urea, processes for preparing the crystalline forms, pharmaceutical formulations thereof, and methods of treating
Pyrrolo[2,3-b]pyridine derivative and use thereof for treatment of cancer
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TECHNICAL FIELD
The present invention relates to a fused heterocycle derivative and use thereof. More particularly, the present invention relates to a compound having a strong Smo inhibitory activity and useful for the prophylaxis or treatment of cancer and the like, and use thereof.
BACKGROUND OF
3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1H-pyrrolo[2,3-C]pyridine derivatives as NIK inhibitors for the treatment of cancer
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a national stage of PCT Application No. PCT/EP2014/058361, filed Apr. 24, 2014, which claims priority for EPO Patent Application No. 13165167.1, filed Apr. 24, 2013 and EPO Patent Application No. 13186116.3, filed Sep. 26, 2013, all of
3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine having anti-tumor activity
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BACKGROUND OF THE INVENTION
The present invention relates to a novel compound, compositions containing the compound, the use of the compound in inhibiting the growth of malignant neoplasms in mammals, and a method of preparing the compound.
A number of chemicals that inhibit the growth or otherwise
Phenyl-pyridine/pyrazine amides for the treatment of cancer
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FIELD OF THE INVENTION
The cyclin-dependent kinase (CDK) complexes are well-conserved Ser/Thr kinase family, and it has been shown to be activated by the binding of regulatory partner, generally a cyclin. There are total 20 CDK family members and 5 CDK-like proteins based on the similarities in
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