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This invention relates to pyridine derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
Up to now, of the compounds having a pyridine skeleton, it has been reported that 2-isopropyl-3-nicotinylindole(L-8027) possesses an inhibitory activity on
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Entra registrati
This invention relates to pyridine derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
Up to now, of the compounds having a pyridine skeleton, it has been reported that 2-isopropyl-3-nicotinylindole(L-8027) possesses an inhibitory activity on
Solo gli utenti registrati possono tradurre articoli
Entra registrati
This invention relates to pyridine derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
Up to now, of the compounds having a pyridine skeleton, it has been reported that 2-isopropyl-3-nicotinylindole(L-8027) possesses an inhibitory activity on
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FIELD OF THE INVENTION
The present invention relates to certain imidazo[1,2-.alpha.]pyridine derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds of Formula (Ia) and pharmaceutical compositions thereof are
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FIELD OF THE INVENTION
The present invention relates to certain imidazo[1,2-a]pyridine derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds of Formula (Ia) and pharmaceutical compositions thereof are directed
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TECHNICAL FIELD
The present invention relates to a pyridine derivative having an ability to act as a neurotrophic factor and a salt thereof.
BACKGROUND ART
It has been suggested that in Alzheimer's disease, which has recently been increasing in prevalence, degeneration and dysfunction of cholinergic
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TECHNICAL FIELD
This invention relates to new pyridine compounds. More particularly, this invention relates to new pyridine compounds and pharmaceutically acceptable salts thereof which have pharmacological activities, a process for preparation thereof, a pharmaceutical composition comprising the
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BACKGROUND OF THE INVENTION
This invention relates to compounds that inhibit the activity of protein kinases. Protein kinases are enzymes that catalyze the transfer of a phosphate group from ATP to an amino acid residue, such as tyrosine, serine, threonine, or histidine on a protein. Regulation of
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The present invention relates to new carboxamides and sulfonamides of the general formula
in which
A denotes a radical ##STR1##
B denotes a radical ##STR2##
W denotes --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.dbd.CH--CH.sub.2 --, --(CH.sub.2).sub.3 --, --CH.sub.2 CH(CH.sub.3)--,
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This invention relates to novel substituted vinyl derivatives which are capable of inhibiting thromboxane A.sub.2 (TXA.sub.2) synthetase specifically.
TXA.sub.2 is one of the arachidonic acid metabolites and is a potent inducer of platelet aggregation and vascular smooth muscle contractions.
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The present invention provides compounds of the formula (I)
##STR00002## wherein R.sub.1 is cycloalkyl, heterocyclyl or an aryl radical of the formula
##STR00003## in which R.sub.4 is cycloalkyl, aryl or heterocyclyl; or R.sub.4 is optionally substituted alkyl, alkoxy, hydroxy, halogen or
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The present invention provides compounds of the formula (I)
##STR00002## wherein R.sub.1 is cycloalkyl, heterocyclyl or an aryl radical of the formula
##STR00003## in which R.sub.4 is cycloalkyl, aryl or heterocyclyl; or R.sub.4 is optionally substituted alkyl, alkoxy, hydroxy, halogen or
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to processes for preparing 2,4-dihydroxypyridine and 2,4-dihydroxy-3-nitropyridine which compounds are intermediates that are useful in preparing adenosine compounds and analogs thereof which are useful in treating
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FIELD OF THE INVENTION
The present invention relates to the use of nitric ester of N-(2-hydroxyethyl) nicotinamide in the treatment of impotence in animals, including humans. More particularly, the present invention relates to the use of N-(2-Hydroxyethyl) nicotinamide, commonly referred to as
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BACKGROUND OF THE INVENTION
T cells play a pivotal role in the regulation of immune responses and are important for establishing immunity to pathogens. In addition, T cells are often activated during inflammatory autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, type I
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