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Pagina 1 a partire dal 19 risultati
Imidazo-pyridine derivatives as ligands for GABA receptors
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The present invention relates to a class of substituted imidazo-pyridine derivatives and to their use in therapy. More particularly, this invention is concerned with imidazo[4,5-b]pyridine analogues which are substituted in the 3-position by a substituted phenyl ring. These compounds are ligands for
Imidazo-pyridine derivatives as ligands for GABA receptors
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The present invention relates to a class of substituted imidazopyridine derivatives and to their use in therapy. More particularly, this invention is concerned with imidazo[1,2-.alpha.]pyridine analogues which are substituted in the 3-position by a substituted phenyl ring. These compounds are
Imidazo-pyridine derivatives as ligands for GABA receptors
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a U.S. National Phase application under 35 U.S.C. .sctn. 371 of PCT Application No. PCT/GB03/02236, filed May 23, 2003, which claims priority under 35 U.S.C. .sctn. 119 from GB Application No. 0212048.3, filed May 24, 2002.
The present
8-fluoroimidazo 1,2-a pyridine derivatives as ligands for GABA receptors
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a U.S. National Phase application under 35 U.S.C. .sctn. 371 of PCT Application No. PCT/GB03/02250, filed May 23, 2003, which claims priority under 35 U.S.C. .sctn. 119 from GB Application No. 0212049.1, filed May 24, 2002.
The present
Pyrazolo-pyridine derivatives as ligands for GABA receptors
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The present invention relates to a class of substituted pyrazolo-pyridine derivatives and to their use in therapy. More particularly, this invention is concerned with substituted and/or ring-fused pyrazolo[3,4-b]pyridine derivatives which are ligands for GABA.sub.A receptors and are therefore useful
Aryl fused substituted 4-oxy-pyridines
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FIELD OF THE INVENTION
This invention relates to substituted 4-oxy-pyridines and more specifically to such compounds that bind to the benzodiazepine site of GABA.sub.A receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in
Aryl fused substituted 4-oxy-pyridines
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FIELD OF THE INVENTION
This invention relates to substituted 4-oxy-pyridines and more specifically to such compounds that bind to the benzodiazepine site of GABA.sub.A receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in
Pyrazolo-pyridine derivatives as ligands for GABA receptors
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The present invention relates to a class of substituted pyrazolo-pyridine derivatives, and to their use in therapy. More particularly, this invention is concerned with substituted pyrazolo[4,3-c]pyridin-3-one analogues which are ligands for GABA.sub.A receptors and are therefore useful in the
Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to heterocyclic amino substituted heteroaryl fused pyridines, and more specifically to such compounds that selectively bind to GABAa receptors. This invention also relates to pharmaceutical compositions comprising such
Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to heterocyclic amino substituted heteroaryl fused pyridines, and more specifically to such compounds that selectively bind to GABAa receptors. This invention also relates to pharmaceutical compositions comprising such
4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: GABA brain receptor ligands
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to certain heterocyclic amino substituted heteroaryl fused pyridines which selectively bind to GABAa receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the
Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to certain fused pyrrolecarboxanilides which selectively bind to GABAa receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in
Tricyclic pyridine derivatives
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BRIEF SUMMARY OF THE INVENTION
The invention relates to compounds of the formula ##STR2## wherein Q.sup.1 and the nitrogen atom taken together are a group of the formula >N--CH.sub.2 CH.sub.2 -- (a), >N--CH.sub.2 CH.sub.2 CH.sub.2 -- (b), >N--CH.dbd.CH-- (c), >N--CH.sub.2 --CH.dbd.CH--
Tricyclic pyridine derivatives
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BRIEF SUMMARY OF THE INVENTION The invention relates to compounds of the formula ##STR2## wherein Q.sup.1 and the nitrogen atom taken together are a group of the formula >N--CH.sub.2 CH.sub.2 -- (a), >N--CH.sub.2 CH.sub.2 CH.sub.2 -- (b), >N--CH=CH-- (c). >N--CH.sub.2 --CH=CH-- (d).
2-aryl-3-heterocyclicmethyl-3H-imidazo[4,5-b]pyridines as anxiolytics and anticonvulsants
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BACKGROUND OF THE INVENTION
The present invention relates to certain novel imidazo[4,5-b]pyridines useful as anxiolytic and anticonvulsant agents, by virtue of their ability to bind to the benzodiazepine receptors and inhibit electrically or chemically induced seizures.
The preparation of fused
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