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Pagina 1 a partire dal 146 risultati
Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase
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ACKNOWLEDGMENT OF FEDERAL RESEARCH SUPPORT
Not applicable.
THE BACKGROUND OF THE INVENTION
The invention relates generally to monoclonal antibodies specific for a neoplasia marker, specifically NADH:protein disulfide reductase, to cell lines producing those neoplastic marker-specific monoclonal
Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer
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FIELD OF THE INVENTION
This invention relates to the diagnosis and treatment of patients at risk for disorders associated with altered methionine synthase activity.
BACKGROUND OF THE INVENTION
Methionine is an essential amino acid in mammals that is required for protein synthesis. Methionine also
Combinations of protein farnesyltransferase and HMG CoA reductase inhibitors and their use to treat cancer
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FIELD OF THE INVENTION
The present invention relates to combinations of compounds that can be used in the medicinal field to treat, prophylactically or otherwise, uncontrolled or abnormal proliferation of human tissues. Specifically, the present invention relates to the combination of (I) compounds
Use of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase as a modality in cancer therapy
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BACKGROUND OF THE INVENTION
The invention relates generally to use of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in treating cancer. More specifically the invention relates to use of lovastatin and its homologues or analogues to treat human adenocarcinoma and selected
Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome
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FIELD OF THE INVENTION
This invention relates to the diagnosis and treatment of patients at risk for disorders associated with altered methionine synthase activity.
BACKGROUND OF THE INVENTION
Methionine is an essential amino acid in mammals that is required for protein synthesis. Methionine also
Combination and method of treatment of cancer utilizing a COX-2 inhibitor and a 3-hydroxy-3-methylglutaryl-coenzyme-a (HMG-CoA) reductase inhibitor
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SUMMARY OF INVENTION
The inventors propose a combination of an HMG-CoA reductase inhibitor (also referred to as "HMG-CoA inhibitor(s)"), and COX-2 inhibitor for the treatment of cancer especially prostate cancer and a method of treatment of cancer by that combination, especially prostate cancer. The
Antisense oligonucleotides directed to ribonucleotide reductase R2 and uses thereof in the treatment of cancer
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FIELD OF THE INVENTION
The present invention pertains to the field of cancer therapeutics and in particular to the use of antisense oligonucleotides alone or in combination with one or more chemotherapeutic drugs for the treatment of cancer.
BACKGROUND
Regulation of ribonucleotide reductase, and
Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to certain novel anti-neoplastic, anti-viral and ribonucleotide reductase catalytic activity affecting pharmaceutical compositions and methods of treatment.
2. Prior Art
Due to the critical role played by iron in the
Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to the killing of neoplastic cells. More specifically, the present invention relates to the use of NADPH cytochrome P450 reductase (RED) to enhance cytochrome P450-based anti-cancer gene therapy.
2. Related
Nitrate reductase-transfected HeLa cells for cancer and microwave bioeffects research
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BACKGROUND OF THE INVENTION
The present invention relates to cervical carcinoma cells (HeLa) modified with a nitrate reductase gene fragment.
U.S. Pat. No. 5,003,050, "Diazoluminomelanin and a method for preparing same", issued Mar. 26, 1991 to Kiel et al, describes a polymeric water-soluble
Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment
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Entra registrati
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to certain novel anti-neoplastic, anti-vital and ribonucleotide reductase catalytic activity affecting pharmaceutical compositions and methods of treatment.
2. Prior Art
Due to the critical role played by iron in the
Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to certain novel anti-neoplastic, anti-vital and ribonucleotide reductase catalytic activity affecting pharmaceutical compositions and methods of treatment.
2. Prior Art
Due to the critical role played by iron in the
Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical conpositions and methods of treatment
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to certain novel anti-neoplastic, anti-viral and ribonucleotide reductase catalytic activity affecting pharmaceutical compositions and methods of treatment.
2. Prior Art
Due to the critical role played by iron in the
Anti-neoplastic, anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to certain novel anti-neoplastic, anti-viral and ribonucleotide reductase catalytic activity affecting pharmaceutical compositions and methods of treatment.
2. Prior Art
Due to the critical role played by iron in the
Anti-neoplastic anti-viral and ribonucleotide reductase activity affecting pharmaceutical compositions and methods of treatment
Solo gli utenti registrati possono tradurre articoli
Entra registrati
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to certain novel anti-neoplastic, anti-vital and ribonucleotide reductase catalytic activity affecting pharmaceutical compositions and methods of treatment.
2. Prior Art
Due to the critical role played by iron in the
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