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reductase/tumore della mammella
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Methods and compositions for regulation of 5-.alpha.-reductase activity
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TECHNICAL FIELD OF THE INVENTION
The present invention relates generally to compounds, compositions methods regulating the action and function of androgens and other steroid hormones by modulating the activity of steroid-reductases, including isozymes of 5.alpha.-reductases. More specifically, the
4-amino-17.beta.-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17.beta.-(cyclopropylamino)androst-4-en-3-one and related compounds as C.sub.17-20 lyase and 5.alpha.-reductase
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BACKGROUND OF THE INVENTION
The enzyme steroid C.sub.17,20 lyase cleaves the 17-20 carbon-carbon bond in steroids having a two carbon side chain at the 17.beta.-carbon position to form important precursor molecules to the formation of testosterone, 5.alpha.-dihydrotestosterone and the estrogens,
4-aza steroids
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BACKGROUND OF THE INVENTION
The enzyme steroid C.sub.17,20 lyase cleaves the 17-20 carbon-carbon bond in steroids having a two carbon side chain at the 17.beta.-carbon position to form important precursor molecules to the formation of testosterone, 5.alpha.-dihydrotestosterone and the estrogens,
20-fluoro-17(20)-vinyl steroids
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to 20-fluoropregna-5,17(20)-diene-3.beta.,21-diol, 20-fluoro-pregna-5,17(20)-dien-3.beta.-ol and related compounds, to processes for their preparation, and to compositions incorporating these compounds as well as the
17.beta.-substituted 4-aza-5.alpha.-androstan-3-one derivatives
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The present invention relates to novel 17.beta.-substituted 4-aza-5.alpha.-androstan-3-one derivatives, to a process for their preparation, and to pharmaceutical compositions containing them. These compounds are inhibitors of androgen action, by means of testosterone 5.alpha.-reductase
Syntheses and methods of use of new antimitotic agents
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FIELD OF THE INVENTION
The present invention relates in general to anticancer agents, and more specifically to synthetic analogs of deoxypreussomerin, palmarumycin CP.sub.1 and related naphthoquinone spiroketals, which exhibit antimitotic activity.
BACKGROUND OF THE INVENTION
The cell cycle consists
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