Patients will tablet acetylsalicylic acid 75mg x 1 for 4 weeks.

Erythropoietin Adverse Reaction

Acetylsalicylic acid

The Effect of Salicylate on Platelet Function in CKD (Chronic Kidney Disease) Patients Treated With Aranesp

The Effect of Low-dose Salicylate Treatment on Platelet Function in Patients With Renal Failure Treated With Darbepoetin Alfa

Multiplate induced with arachidonic acid, ADP (adenosine diphosphate) and TRAP (Thrombin receptor-activating peptid)

Total platelet count (units per milliliters)

platelet distribution width (fL = femtoliters)

immature platelet count (platelets/microliter)

Zealand University Hospital

Self-administered metformin (patient's usual dose) taken 2 hours prior to surgery

Self-administered salsalate taken 2 hours prior to surgery

Self-administered placebo taken 2 hours prior to surgery

Diabetes Mellitus, Type 2

Hyperglycemia

Perioperative/Postoperative Complications

Metformin (usual dose) administered 2 h before surgery

Metformin

Salsalate 1.5 g administered 2 h before surgery

Salsalate

Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control

Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control - A Placebo-Controlled Internal Feasibility Trial

Percentage (%) of individuals who were approached in the pre-operative clinic that enrolled in the study

Detect change in hyperglycemic events (glucose >11mmol/L) at the 4 blood sampling time points for each participant

Number (n) of individuals recruited each month

Evaluation of glycemic control by calculating mean blood glucose levels obtained at 4 time points

Measured using validated biomarkers (IL-6, tumor necrosis factor, high-sensitivity C reactive protein), and surgical site infections recorded within 6 weeks of surgery

McMaster University

Parallel, placebo-controlled trial with block randomization

Patients will be randomized on the day of their pre-operative assessment by our department statistician using a computer-generated table, with an allocation ratio of 1:1:1 in random permuted blocks of 3 or 6. Only the pharmacist and statistician will know the allocation sequence. Concealed medications (over-encapsulated) will be provided to the RC upon confirming the allotment with a unique identification number (UIN), recorded on the patient-specific case record form (CRF).

Cutaneous Leishmaniasis

daily nitric oxide patch application during 20 days

controlled nitric oxide releasing patch

meglumine antimoniate

Fundación Cardiovascular de Colombia

Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

Double Blind, Randomized Controlled Trial, to Evaluate the Effectiveness of a Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

salicylic acid/nausea

The Effect of Salicylate on Platelet Function in CKD (Chronic Kidney Disease) Patients Treated With Aranesp

Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control

Controlled Nitric Oxide Releasing Patch Versus Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis

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