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12 risultati
Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents
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1. INTRODUCTION
The present invention relates to a novel method of controlling nausea and vomiting (or emesis) in mammals utilizing certain substituted-phenylalkylamino (and aminoacid) derivatives which do not exhibit certain side effects of the type attributable to dopamine blocking compounds which
Pharmaceutical compositions containing quinazoline derivatives for treating as serotonin receptor antagonist
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CROSS-REFERENCE TO RELATED APPLICATION
This application claims, under 35 U.S.C. .sctn.119(a), the benefit of Korean Patent Application No. 10-2007-0084322 filed Aug. 22, 2007, the entire contents of which are incorporated herein by reference.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The
Methods for treating emesis and nausea using optically pure R(+) ondansetron
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BACKGROUND OF THE INVENTION
This invention relates to novel compositions of matter containing optically pure R(+) ondansetron. These novel compositions have potent antiemetic activity and are useful in ameliorating the nausea and vomiting otherwise induced by cancer chemotherapeutic agents and
4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
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This application claims the benefit of Provisional Application 60/069,890 Jan. 5, 1996.
The present invention is directed to certain novel compounds and their use as pharmaceutical agents having unique central nervous system activity.
This invention relates to 4,5-dihydronaphth[1,2-c]isoxazoles and
Deuterium-enriched pyridinonecarboxamides and derivatives
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SUMMARY OF THE INVENTION
The present invention is concerned with deuterium-enriched pyridinone carboxamides and derivatives thereof of formula I,
##STR00002##
Wherein, R.sub.1 and R.sub.2 are independently, H, D (deuterium with enrichment of 1%-100%), F, Cl, CD.sub.3 (methyl-d.sub.3),
Deuterium-enriched pyridinonecarboxamides and derivatives
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SUMMARY OF THE INVENTION
The present invention is concerned with deuterium-enriched pyridinonecarboxamides and derivatives thereof of formula 1,
##STR00002## Wherein, R.sub.1 and R.sub.2 are independently, H, D (deuterium with enrichment of 1%-100%), F, Cl, CD.sub.3 (methyl-d.sub.3),
Derivatives of amide analogs of certain methano bridged quinolizines
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This invention relates to novel amide derivatives of certain 2,6-methano-2H-quinolizines-type compounds, to the intermediates and processes for their preparation, to their ability to antagonize the effects of serotonin at the 5HT.sub.3 receptors, and to their end-use application in the treatment of
Methods for treating behavioral and other disorders using optically pure R(+) ondansetron
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BACKGROUND OF THE INVENTION
This invention relates to novel compositions of matter containing optically pure R(+) ondansetron. These novel compositions have potent antiemetic activity and are useful in ameliorating the nausea and vomiting otherwise induced by cancer chemotherapeutic agents and
Compositions using optically pure R(+) ondansetron
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BACKGROUND OF THE INVENTION
This invention relates to novel compositions of matter containing optically pure R(+) ondansetron. These novel compositions have potent antiemetic activity and are useful in ameliorating the nausea and vomiting otherwise induced by cancer chemotherapeutic agents and
Method treating cognitive disorders using optically pure R(+) ondansetron
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BACKGROUND OF THE INVENTION
This invention relates to novel compositions of matter containing optically pure R(+) ondansetron. These novel compositions have potent antiemetic activity and are useful in ameliorating the nausea and vomiting otherwise induced by cancer chemotherapeutic agents and
Cinnoline-3-carboxylic acid derivatives
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FIELD OF THE INVENTION
This invention relates to a cinnoline derivative which is pharmaceutically useful as an antagonist against serotonin 5-HT.sub.3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical compositions containing the
Cinnoline-3-carboxylic acid derivatives
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FIELD OF THE INVENTION
This invention relates to a cinnoline derivative which is pharmaceutically useful as an antagonist against serotonin 5-HT.sub.3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical compositions containing the
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