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Pagina 1 a partire dal 89 risultati
Methods for the treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration
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TECHNICAL FIELD OF THE INVENTION
This invention relates to pharmaceutical compositions useful for treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration, and to methods for using the compositions.
BACKGROUND OF THE INVENTION
Neurotrophic factors exhibit a trophic effect
Sequences characteristic of hypoxia-regulated gene transcription
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BACKGROUND OF THE INVENTION
1. Technical Field
The present invention relates to the identification of genes that are differentially expressed in hypoxia and use of the genes and gene products for diagnosis and therapeutic intervention. The invention further relates to identification of
Sequences characteristic of hypoxia-regulated gene transcription
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BACKGROUND OF THE INVENTION
1. Technical Field
The present invention relates to the identification of genes that are differentially expressed in hypoxia and use of the genes and gene products for diagnosis and therapeutic intervention. The invention further relates to identification of
Compositions and methods for treating neural anoxia and spreading depression
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FIELD OF THE INVENTION
The present invention relates to compositions and methods for protecting neural tissue from anoxia and/or spreading depression. The present invention further relates to compositions and methods for mitigating side effects associated with pharmaceuticals that manipulate the
Differential expression of molecules associated with acute stroke
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FIELD
This application relates to methods of evaluating an ischemic stroke, methods of identifying a treatment modality for a subject who has had an ischemic stroke, methods of identifying compounds that alter the activity of an ischemic stroke-related molecule, as well as arrays and kits that can
Genes involved in stroke response and/or regulated by FK506, proteins encoded thereby, and methods of use
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FIELD OF THE INVENTION
The present invention relates to genes and the proteins encoded thereby which are involved in neurotoxicity and/or are regulated by FK506. Polynucleotides were discovered using in vivo or in vitro models by determining which genes were differentially upregulated or
Diacid-containing benzimidazole compounds for treatment of neurotoxic injury
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FIELD OF THE INVENTION
This invention is in the field of clinical neurology and relates specifically to a class of compounds, compositions and methods for neuro-protective purposes such as controlling chronic or acute neurotoxic injury or brain damage resulting from neuro-degenerative diseases. For
N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury
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FIELD OF THE INVENTION
This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for neuroprotective purposes such as controlling brain damage which occurs during periods of anoxia or ischemia associated with stroke, cardiac arrest or
Method and apparatus for detection of vulnerable atherosclerotic plaque
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention generally relates to methods of diagnosing and treating inflammation, particularly inflamed atherosclerotic plaque at risk of rupture or thrombosis. More particularly, the methods of the invention pertain to the simultaneous
Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury
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FIELD OF THE INVENTION
This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for neuroprotective purposes such as controlling brain damage which occurs during periods of anoxia or ischemia associated with conditions such as stroke,
Method of using alkenyl- or alkynyl-substituted thiobarbiturates to reduce neurotoxic injury
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FIELD OF THE INVENTION
This invention is in the field of clinical neurology and relates specifically to methods and compositions for neuroprotective purposes such as controlling brain damage which occurs during periods of anoxia or ischemia associated with stroke, cardiac arrest or perinatal
Imidazole compounds and their use as calcium channel blockers
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The present invention relates to therapeutically-active compounds and their use as well as to pharmaceutical preparations comprising the compounds. The compounds of the invention possess valuable activity as calcium channel blockers which make them useful in the treatment of anoxia, ischemia,
Medical uses of allosteric hemoglobin modifier compounds in patient care
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DESCRIPTION
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention generally relates to using a family of compounds to adjust the allosteric equilibrium of hemoglobin toward a low oxygen affinity state. Moreover, the invention includes several new compounds and contemplates
Kinase inhibitors, compositions thereof, and methods of use therewith
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2. FIELD
Provided herein are certain guanidinyl hydrazone-substituted compounds and derivatives, compositions comprising such compounds and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a disease, disorder or condition treatable or preventable by
Compositions containing and methods of using N-acyl-1H-aminoindenes
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Throughout this application, various references are identified by authors and full citation. Disclosure of these publications in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains.
BACKGROUND OF THE
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