threonine/infiammazione

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Mindfulness-Based Health Promotion Program for Educators (MBHP - Educa).

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In the last few decades, the world has seen a significant increase in the occurrence of occupational diseases related to Burnout Syndrome (professional exhaustion) and stress in educators. These disorders affect mental health and teaching activity. In this way, they need to develop socio-emotional

mTOR and Adipose Tissue Inflammation

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Mechanism of Sorafenib Resistance in Patients With Advanced Hepatocellular Carcinoma

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Introduction Hepatocellular carcinoma (HCC) is a major health problem, accounting for more than 626,000 new cases per year worldwide. It is the third highest cause of cancer-related death globally. In the west, the disease is diagnosed in 30 to 40% of all patients at early stages and is amenable to

suPERficial Slow-flow Vascular malFORMations Treated With sirolimUS

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Vascular anomalies include a heterogeneous group of disorders of newborns and children. While infantile hemangioma are common (10% of infants), generally not complicated and easily managed, the majority of other vascular anomalies are rare (<2% altogether) and have no guidelines for management. The

Effects of High vs. Standard Protein Intake in Newborn Extreme Premature

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METHODS: Types of study: randomized single-blinded clinical trial. Time and place of development: Neonatology Service (NICU, Neonatal Ward and Premature Ward) in the Unidad Medica de Alta Especialidad Número 48, of Instituto Mexican del Seguro Social in Leon, Mexico, in the period between 1st of

The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome

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Metabolic syndrome is a cluster of biochemical and physiological abnormalities associated with the development of cardiovascular disease and type 2 diabetes mellitus. The current study focused on type 2 Diabetes Mellitus(T2DM). T2DM is a chronic disease in which people have problems regulating their

Phase I Dose Escalation and Expansion of Oral BAY 1143269 in Combination With Intravenous Docetaxel

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BAY 1143269 is a potent and selective, orally administered novel inhibitor of mitogen-activated protein kinase interacting serine/threonine-protein kinase 1 (MKNK1). MKNK1 activity is essential for the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E), which promotes the

Threonine Requirement in IBD Adults and Healthy Adult Controls

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Threonine is an essential amino acid which must be obtained from the diet. It is a component of mucin. Mucin, in turn, is a key protein in the mucous membrane that protects the lining of the intestine. Inflammatory bowel disease (IBD) is a group of inflammatory conditions that affect the colon and

An Observational Case Control Study to Identify the Role of MV and MV Derived Micro-RNA in Post CArdiac Surgery AKI

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AKI is characterised by upregulation of competing pro-survival and pro- inflammatory/ apoptotic signaling pathways whereby processes associated with renal recovery; tubular epithelial phenotypic change and proliferation occur simultaneously with those associated with diminished GFR, vascular

Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People

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Objective Translocator protein 18 kDa (TSPO) is highly expressed in activated microglia and reactive astrocytes in brain, and it may, thereby, be a useful biomarker of neuroinflammation. We developed [(11)C]PBR28 as a positron emission tomographic (PET) radioligand to bind to TSPO and measure its

Amino Acids Expression Profiling of Patients With Sepsis

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Brain P-gp and Inflammation in People With Epilepsy

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Objectives: 1. To study the role of inflammation in focal epilepsy 2. To characterize the BBB state in patients with focal epilepsy using MRI, and compare the results with PET imaging of inflammation 3. To study test-retest replicability of [11C]PBR28 PET scanning. Study population: 50 participants

A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease

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Inflammatory Bowel Disease (IBD) in childhood are chronic relapsing and remitting inflammatory condition that have a significant impact on growth and development. IBD involves a shift from a regulated intestinal immune response to one that is driven by unrestrained immune cell activation and

Multi-faceted Evaluations Following Weight Reduction in Subjects With Metabolic Syndrome

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Obesity, in particular central obesity, has been one of the important documented risk factors for development of diabetes and cardiovascular disease. Recent re-delineated various versions of definitions of metabolic syndrome, has fueled further the critical involvement of central adiposity in these

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