Adipose tissue sampling in obese volunteers (BMI > 35kg/m2) aged 18- max. 60 years, males and females; insulin-resistant, scheduled for elective bariatric surgery

Adipose tissue sampling in normal weight patients (BMI < 27kg/m2) aged 18- max. 60 years, males and females; insulin-sensitive, scheduled for elective surgery

Adipose tissue sampling in obese volunteers (BMI > 35kg/m2) aged 18- max. 60 years, males and females; diabetic, scheduled for elective bariatric surgery

Obesity

Adipose tissue sampling

mTOR and Adipose Tissue Inflammation

mTOR and Adipose Tissue Inflammation in Humans

measurement of mTORC2 activity in adipose tissue once at surgery

measurement of Mcp1 messenger ribonucleic acid (mRNA) level in adipose tissue once at surgery

measurement of fasting plasma insulin and fasting Glucose once at surgery

University Hospital, Basel, Switzerland

Group under the treatment ( sorafenib ) Maximum dose of 400 mg BID If subjects devolves adverse events, dose can be reduced.

Hepatocellular Carcinoma

Liver lesion biopsy (HCC) and blood samples will be taken from the subjects before starting the treatment course, and another biopsy and blood samples when they devolve a resistance.

Sorafenib

King Saud University Medical City

Mechanism of Sorafenib Resistance in Patients With Advanced Hepatocellular Carcinoma

Samples will be sequenced using second generation sequencing comparison between, before and after therapy signature will be identified.

Mazen Hassanain

Assocaite Professor of Surgery and Consultant HPB and Transplant Surgery

King Saud University

King Faisal Specialist Hospital & Research Center

Patient sample within the normal range of blood results.

Patient sample from freshly diagnosed Type 2 Diabetes Mellitus.

Whole blood is collected and blood component separated for the future use. Whole blood, red blood cells, plasma and buffy coat are was separated and kept in -80 degree Celsius.

Type 2 Diabetes Mellitus

Lipid bodies inflammatory cells: structure, function, and current imaging techniques

The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography

The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition

Lipid body formation during maturation of human mast cells

Balancing the fat: lipid droplets and human disease

Is fat so bad? Modulation of endoplasmic reticulum stress by lipid droplet formation

The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage

Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells

Differences in the behavior of cytoplasmic granules and lipid bodies during human lung mast cell degranulation

Differential roles for triglyceride and phospholipid pools of arachidonic acid in human lung macrophages

Co-compartmentalization of MAP kinases and cytosolic phospholipase A2 at cytoplasmic arachidonate-rich lipid bodies

Migration of human inflammatory cells into the lung results in the remodeling of arachidonic acid into a triglyceride pool

Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a monocyte chemotactic protein 1/ chemokine ligand 2 (MCP-1/CCL2) regulated phenomenon

Lipid body function in eicosanoids synthesis : An update

University Malaya Medical Center (UMMC)

The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome

The Role of Arachidonic Acid Metabolites, in the Lipid Droplets of Macrophages From Patients With Metabolic Syndrome

Gracie Ong @ Gracie Ong Siok Yan

Senior Consultant

University of Malaya

Life-style modification for 40 study subjects with metabolic syndrome in comparison to 25 non-obesity subjects for control.

Metabolic Syndrome

Lifestyle Counseling

Taichung Veterans General Hospital

Multi-faceted Evaluations Following Weight Reduction in Subjects With Metabolic Syndrome

Study of Wight Reduction by Life-style Modification

Wayne Huey-Herng Sheu

fast from midnight the night before surgery, and consume 400 ml Nutricia preOp® (12.5% carbohydrates, 0.5 kcal/ml, 240 mOsm, pH 4.9, Nutricia Zoetermeer, The Netherlands) 3 hours prior to induction of anaesthesia and finished the ingestion within 1 hour

fast from midnight the night before surgery, and no preoperative oral carbohydrate loading

Colorectal Disease

Patients in OCH group consumed 400 ml Nutricia preOp® (12.5% carbohydrates, 0.5 kcal/ml, 240 mOsm, pH 4.9, Nutricia Zoetermeer, The Netherlands) 3 hours prior to induction of anaesthesia and finished the ingestion within 1 hour

Preoperative Oral Carbohydrate

Patients in FSD group were fasted from midnight the night before surgery, and no preoperative oral carbohydrate loading

threonine/obesità

mTOR and Adipose Tissue Inflammation

Mechanism of Sorafenib Resistance in Patients With Advanced Hepatocellular Carcinoma

The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome

Multi-faceted Evaluations Following Weight Reduction in Subjects With Metabolic Syndrome

The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway

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