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Pagina 1 a partire dal 17 risultati
Indole and indazole urea-peptoids as thrombin receptor antagonists
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FIELD OF THE INVENTION
This invention relates to certain novel thrombin receptor antagonists, their synthesis and their use for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic
Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT1B/1D ligands
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The invention relates to amide and urea derivatives of the formula I
in which R.sup.1 is 3-indolyl which is unsubstituted or mono- or disubstituted by A, AO, OH, Hal, CN, NO.sub.2, NH.sub.2, NHA, NA.sub.2, COA, CONH.sub.2, CONHA, CONA.sub.2, CH.sub.2 OH, CH.sub.2 OA, CH.sub.2 NH.sub.2, CH.sub.2 NHA,
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
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FIELD OF THE INVENTION
The present invention relates to certain diaryl and arylheteroaryl urea derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
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Entra registrati
FIELD OF THE INVENTION
The present invention relates to certain diaryl and arylheteroaryl urea derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT.sub.2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
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Entra registrati
FIELD OF THE INVENTION
The present invention relates to certain diaryl and arylheteroaryl urea derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT.sub.2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
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Entra registrati
FIELD OF THE INVENTION
The present invention relates to certain diaryl and arylheteroaryl urea derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT.sub.2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to
Urethanes, ureas, amidines and related inhibitors of factor Xa
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FIELD OF THE INVENTION
This invention relates to a new class of compounds, which are potent and highly selective inhibitors of factor Xa, both isolated and when assembled in a complex with other proteins. In another aspect the invention relates to a new class of compounds, their pharmaceutically
Urea and thiourea derivatives
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FIELD OF THE INVENTION
This invention relates to urea and thiourea derivatives, which are useful for the inhibiting of the enzyme nicotinamide phosphoribosyltransferase (NAMPRT), and to medical use of such derivatives.
BACKGROUND OF THE INVENTION
Inhibition of the enzyme nicotinamide
Substituted ureas as cell adhesion inhibitors
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SUMMARY OF THE INVENTION
The compounds of the present invention are antagonists of the VLA-4 integrin ("very late antigen-4"; CD49d/CD29; or .alpha..sub.4.beta..sub.1), the .alpha.4.beta.7 integrin (LPAM-1 and .alpha..sub.4.beta..sub.p), and/or the .alpha.9.beta.1 integrin, thereby blocking the
Urea and thiourea derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
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FIELD OF THE INVENTION
The present invention concerns novel urea and thiourea derivatives of substituted quinoxaline 2,3-diones having utility as glutamate receptor antagonists. The fused ring quinoxaline 2,3-dione system is substituted at the a- or b-position by urea or thiourea derivatives. The
Urea compounds and their use as enzyme inhibitors
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FIELD OF THE INVENTION
The present invention relates to compounds and their uses, and in particular to compounds and their therapeutic use in the treatment or prevention of conditions having an association with substrates, such as the neurotransmitter anandamide, which are broken down by the fatty
Urea compounds and their use as enzyme inhibitors
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FIELD OF THE INVENTION
The present invention relates to compounds and their uses, and in particular to compounds and their therapeutic use in the treatment or prevention of conditions having an association with substrates, such as the neurotransmitter anandamide, which are broken down by the fatty
Optical sensor device and image processing unit for measuring chemical concentrations, chemical saturations and biophysical parameters
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FIELD OF THE INVENTION
The present invention relates to image processing units and optical sensor devices for obtaining biophysical, biochemical, physiological and vital sign information from an array of photodetectors or from video image data including stored video image data.
BACKGROUND OF THE
Compositions and methods for the treatment of metabolic syndrome
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PRIORITY
This application is a national phase filing of the Patent Cooperation Treaty (PCT) application # PCT/IB2013/050904 titled COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME filed on Feb. 3, 2013 Published with WIPO Publication # WO/2013/167996, which further claims priority to
Compositions and methods for the treatment of metabolic syndrome
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PRIORITY
The present application claims the benefit of Indian Provisional Patent Application No. 1836/CHE/2012 filed on 10 May 2012 and the International Application No. PCT/IB2013/050907 filed on 3 Feb. 2013; the entire disclosure of which is relied on for all purposes and is incorporated into this
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