Lidocaine 1.5mg/kg IVPB in 50ml normal saline over 10 minutes (active experimental) and normal saline 1ml intravenous push injection (placebo)

Ketorolac 30mg (1ml) intravenous push injection (active intervention) and Normal saline 50ml IVPB over 10 minutes (placebo)

Renal Colic

Lidocaine 1.5mg/kg IVPB in 50ml normal saline over 10 minutes x 1dose

Lidocaine

Ketorolac 30mg (1ml) intravenous push injection x 1dose

Ketorolac

The Brooklyn Hospital Center

Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department

Lidocaine Versus Ketorolac for the Management of Renal Colic

Patient's perception of pain as described by the use of numeric rating scale (NRS) at 15 minutes after initial study interventions

incidence of arrhythmia (atrial fibrillation, ventricular tachycardia, ventricular fibrillation)

incidence of respiratory depression (respiratory rate less than 12bpm)

incidence of oxygen saturation less than 90%

the number of patients who consumed an adjuvant pain medication for analgesia.

This is a double-blind placebo-controlled randomized trial where blinding will be conducted and applied to the study investigator, physicians, and nursing staff providing care to the patient. An independent biostatistician will conduct a statistical analysis with blinded data. Only the pharmacists preparing the study interventions will be unblended to the study treatments. The pharmacists procuring the interventions will not be part of data collection or analysis.

Ivabradine will be administered at a dose of 5 mg twice daily in addition to a low dose of beta-blocker (bisoprolol 1,25 or 2,5 mg). After four weeks of treatment ivabradine will be eventually lowered up to 2,5 mg twice daily in the presence of side effects (phosphenes, diplopia, headache or dizziness).

Beta blocker Bisoprolol will be titrated biweekly starting from the initial dose of 1,25-2,5 mg daily up to the max dose of 10 mg daily or to the maximum tolerated dose.

Heart Rate Control in ICD Patients With Heart Failure

Ivabradine plus beta-blocker (bisoprolol)

Beta blocker Bisoprolol will be up-titrated biweekly starting from the initial dose of 1,25-2,5 mg daily up to the max dose of 10 mg daily or to the maximum tolerated dose.

betablocker titration

Polinico Casilino

Effect of Ivabradine and Beta-blockers Combination Versus Beta-blockers Up-titration on Right Ventricular Pacing

Effect of Heart Rate Control Using Ivabradine and Beta-blockers Combination Versus Beta-blockers Up-titration on Ventricular Pacing in Heart Failure Patients With an Implanted Cardioverter Defibrillator.

ventricular fibrillation/cefalea

Lidocaine vs Ketorolac for Management of Renal Colic in the Emergency Department

Effect of Ivabradine and Beta-blockers Combination Versus Beta-blockers Up-titration on Right Ventricular Pacing

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