[Expression and significance of vascular permeability factor (VPF) in inflammatory cells of nasal polyps].

OBJECTIVE

To study the expression and significance of vascular permeability factor (VPF) in eosinophil, macrophage and plasma cell in nasal polyps.

METHODS

VPF in 12 nasal polyps was studied by immunohistochemistry, double immune-enzymatic staining technique and double MGG staining technique. Each section was observed under optical microscope.

RESULTS

Immunohistochemistry result: VPF was detected in the cells showing morphological feature of plasma cells. Double immune-enzymatic staining result: CD68 positive cells in the second staining conformed to VPF positive cells in the first staining. MGG and immune-enzymatic double staining result: eosinophils in MGG staining were in conformity with some VPF positive cells.

CONCLUSIONS

Positive expression of VPF in eosinophils, macrophages and plasma cells indicates that VPF may play a role in the formation of heavy edema of nasal polyps.